Literature DB >> 21641542

A radical role for TOR in longevity.

Dudley W Lamming1, David M Sabatini.   

Abstract

TOR (target of rapamycin) signaling regulates life span in many organisms, but the mechanism behind the effect is unknown. In this issue of Cell Metabolism, Pan and colleagues (2011) find that reduced TORC1 activity promotes yeast life span via a mechanism that, paradoxically, relies upon the production of normally deleterious reactive oxygen species.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21641542      PMCID： PMC3121179          DOI： 10.1016/j.cmet.2011.05.006

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Hot topics in aging research: protein translation and TOR signaling, 2010.

Authors:  Matt Kaeberlein; Brian K Kennedy
Journal:  Aging Cell       Date:  2011-01-20       Impact factor: 9.304

2.  Sir2 blocks extreme life-span extension.

Authors:  Paola Fabrizio; Cristina Gattazzo; Luisa Battistella; Min Wei; Chao Cheng; Kristen McGrew; Valter D Longo
Journal:  Cell       Date:  2005-11-18       Impact factor: 41.582

3.  A genomic analysis of chronological longevity factors in budding yeast.

Authors:  Christopher R Burtner; Christopher J Murakami; Brady Olsen; Brian K Kennedy; Matt Kaeberlein
Journal:  Cell Cycle       Date:  2011-05-01       Impact factor: 4.534

4.  SOD2 functions downstream of Sch9 to extend longevity in yeast.

Authors:  Paola Fabrizio; Lee-Loung Liou; Vanessa N Moy; Alberto Diaspro; Joan Selverstone Valentine; Edith Butler Gralla; Valter D Longo
Journal:  Genetics       Date:  2003-01       Impact factor: 4.562

5.  Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity.

Authors:  Ana Mesquita; Martin Weinberger; Alexandra Silva; Belém Sampaio-Marques; Bruno Almeida; Cecília Leão; Vítor Costa; Fernando Rodrigues; William C Burhans; Paula Ludovico
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-09       Impact factor: 11.205

6.  Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.

Authors:  Tim J Schulz; Kim Zarse; Anja Voigt; Nadine Urban; Marc Birringer; Michael Ristow
Journal:  Cell Metab       Date:  2007-10       Impact factor: 27.287

7.  A molecular mechanism of chronological aging in yeast.

Authors:  Christopher R Burtner; Christopher J Murakami; Brian K Kennedy; Matt Kaeberlein
Journal:  Cell Cycle       Date:  2009-04-23       Impact factor: 4.534

8.  Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.

Authors:  Cheol Woong Ha; Won-Ki Huh
Journal:  Nucleic Acids Res       Date:  2010-10-14       Impact factor: 16.971

9.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Authors:  David E Harrison; Randy Strong; Zelton Dave Sharp; James F Nelson; Clinton M Astle; Kevin Flurkey; Nancy L Nadon; J Erby Wilkinson; Krystyna Frenkel; Christy S Carter; Marco Pahor; Martin A Javors; Elizabeth Fernandez; Richard A Miller
Journal:  Nature       Date:  2009-07-08       Impact factor: 49.962

10.  MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

Authors:  Oliver Medvedik; Dudley W Lamming; Keyman D Kim; David A Sinclair
Journal:  PLoS Biol       Date:  2007-10-02       Impact factor: 8.029
  10 in total
  4 in total

Review 1.  Lifespan modulation in mice and the confounding effects of genetic background.

Authors:  Lorna Mulvey; Amy Sinclair; Colin Selman
Journal:  J Genet Genomics       Date:  2014-06-14       Impact factor: 4.275

2.  Two-meal caloric restriction induces 12-hour rhythms and improves glucose homeostasis.

Authors:  Nikkhil Velingkaar; Volha Mezhnina; Allan Poe; Roman V Kondratov
Journal:  FASEB J       Date:  2021-02       Impact factor: 5.834

Review 3.  Unraveling the message: insights into comparative genomics of the naked mole-rat.

Authors:  Kaitlyn N Lewis; Ilya Soifer; Eugene Melamud; Margaret Roy; R Scott McIsaac; Matthew Hibbs; Rochelle Buffenstein
Journal:  Mamm Genome       Date:  2016-06-30       Impact factor: 2.957

4.  Caloric restriction effects on liver mTOR signaling are time-of-day dependent.

Authors:  Richa Tulsian; Nikkhil Velingkaar; Roman Kondratov
Journal:  Aging (Albany NY)       Date:  2018-07-16       Impact factor: 5.682
  4 in total

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