| Literature DB >> 21641211 |
Shaun R Selness1, Rajesh V Devraj, Balekudru Devadas, John K Walker, Terri L Boehm, Richard C Durley, Huey Shieh, Li Xing, Paul V Rucker, Kevin D Jerome, Alan G Benson, Laura D Marrufo, Heather M Madsen, Jeff Hitchcock, Tom J Owen, Lance Christie, Michele A Promo, Brian S Hickory, Edgardo Alvira, Win Naing, Radhika Blevis-Bal, Dean Messing, Jerry Yang, Michael K Mao, Gopi Yalamanchili, Richard Vonder Embse, Jeffrey Hirsch, Matthew Saabye, Sheri Bonar, Elizabeth Webb, Gary Anderson, Joseph B Monahan.
Abstract
The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are described. Systematic structural modifications to the HTS lead, 5, led to the identification of (-)-4a as a clinical candidate for the treatment of inflammatory diseases. Additionally, the chiral synthesis and properties of (-)-4a are described.Entities:
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Year: 2011 PMID： 21641211 DOI： 10.1016/j.bmcl.2011.04.121
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823