| Literature DB >> 21640741 |
Victoria Richmond1, Gustavo A Garrido Santos, Ana P Murray, Marta S Maier.
Abstract
Disodium 2β,3α-dihydroxy-5α-cholestan-6-one disulfate (8) has been synthesized using cholesterol (1) as starting material. Sulfation was performed using trimethylamine-sulfur trioxide complex in dimethylformamide as the sulfating agent. The acetylcholinesterase inhibitory activity of compound 8 was evaluated and compared to that of disodium 2β,3α-dihydroxy-5α-cholestane disulfate (10) and diols 7 and 9. Compounds 8 and 10 were active with IC(50) values of 14.59 and 59.65 μM, respectively. Diols 7 and 9 showed no inhibitory activity (IC(50)>500 μM).Entities:
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Year: 2011 PMID： 21640741 DOI： 10.1016/j.steroids.2011.05.005
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668