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Literature DB >> 21640584

Sensitive luciferin derived probes for selective carboxypeptidase activity.

Yu-Cheng Chang¹, Pei-Wen Chao, Ching-Hsuan Tung.

Abstract

Highly selective luminescent probes, QLUC-TYR and LUC-GLU, for detection of carboxypeptidase activity were synthesized. Caged substrates were first cleaved by corresponding carboxypeptidases, and then they were activated by luciferase to emit light. Enzymatic activities of biologically important carboxypeptidases can be determined using this technology.

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Year: 2011 PMID： 21640584 PMCID： PMC3129288 DOI： 10.1016/j.bmcl.2011.05.023

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

23 in total

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Journal: Nat Methods Date: 2006-04 Impact factor: 28.547

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