OBJECTIVE: The purpose of this study is to describe the effects in the placebo and "no treatment" arms in trials with headache patients. METHOD: This is a secondary analysis of randomized controlled trials from 8 systematic reviews and selected trials with a "no treatment" or placebo control group. The different types of "no treatment" and placebo interventions were assessed and classified into 6 subgroups. The analyses were carried out according to type of outcome variable. RESULTS: In total, 119 studies were included (7119 participants). The mean recovery rate in all control groups was 35.7%. Significantly more participants recovered in control groups of pharmacological studies than in nonpharmacological studies: 38.5% vs 15.0%, respectively. Adults were more likely to recover in nonpharmacological studies and children in pharmacological studies. CONCLUSIONS: The mean recovery rate in the control groups was 36%. The recovery rate varied substantially between type of intervention and patients.
OBJECTIVE: The purpose of this study is to describe the effects in the placebo and "no treatment" arms in trials with headachepatients. METHOD: This is a secondary analysis of randomized controlled trials from 8 systematic reviews and selected trials with a "no treatment" or placebo control group. The different types of "no treatment" and placebo interventions were assessed and classified into 6 subgroups. The analyses were carried out according to type of outcome variable. RESULTS: In total, 119 studies were included (7119 participants). The mean recovery rate in all control groups was 35.7%. Significantly more participants recovered in control groups of pharmacological studies than in nonpharmacological studies: 38.5% vs 15.0%, respectively. Adults were more likely to recover in nonpharmacological studies and children in pharmacological studies. CONCLUSIONS: The mean recovery rate in the control groups was 36%. The recovery rate varied substantially between type of intervention and patients.
Authors: M C Jong; I Boers; H A van Wietmarschen; E Tromp; J O Busari; R Wennekes; I Snoeck; J Bekhof; A M Vlieger Journal: Eur J Pediatr Date: 2018-10-24 Impact factor: 3.183
Authors: Joerg Schiller; Matthias Karst; Tim Kellner; Wen Zheng; Daniel Niederer; Lutz Vogt; Isabelle Eckhardt; Florian Beissner; Christoph Korallus; Christian Sturm; Christoph Egen; Christoph Gutenbrunner; Matthias Georg Fink Journal: Cephalalgia Date: 2021-02-09 Impact factor: 6.292