| Literature DB >> 21639096 |
Keith R Fandrick1, Daniel R Fandrick, Jonathan T Reeves, Joe Gao, Shengli Ma, Wenjie Li, Heewon Lee, Nelu Grinberg, Bruce Lu, Chris H Senanayake.
Abstract
An operationally simple copper-BINAP-catalyzed, highly enantioselective propargylation of ketones is presented. The methodology was developed as an enantioselective process for methyl ethyl ketone and shown to be applicable to a wide variety of prochiral ketones. The resulting homopropargyl adducts are versatile latent carbonyls from which γ-butyrolactones, β-hydroxy methyl ketones, and β-hydroxycarboxylates are readily obtained.Entities:
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Year: 2011 PMID： 21639096 DOI： 10.1021/ja2028958
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419