Literature DB >> 21636324

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.

YiXiong Heng1, Peck Gee Seah, Jie Yee Siew, Hui Chien Tay, Amit Singhal, Vanessa Mathys, Mehdi Kiass, Pablo Bifani, Véronique Dartois, Maxime Hervé.   

Abstract

Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21636324     DOI： 10.1016/j.tube.2011.05.003

Source DB:  PubMed          Journal:  Tuberculosis (Edinb)        ISSN： 1472-9792            Impact factor:   3.131


  8 in total

Review 1.  Metabolic Perspectives on Persistence.

Authors:  Travis E Hartman; Zhe Wang; Robert S Jansen; Susana Gardete; Kyu Y Rhee
Journal:  Microbiol Spectr       Date:  2017-01

2.  T cell monitoring of chemotherapy in experimental rat tuberculosis.

Authors:  Damian Guang Foo; Hui Chien Tay; Jie Yee Siew; Amit Singhal; Luis Camacho; Pablo Bifani; Véronique Dartois; Maxime Hervé
Journal:  Antimicrob Agents Chemother       Date:  2011-05-31       Impact factor: 5.191

3.  Hypoxia in Leishmania major skin lesions impairs the NO-dependent leishmanicidal activity of macrophages.

Authors:  Alexander Mahnke; Robert J Meier; Valentin Schatz; Julian Hofmann; Kirstin Castiglione; Ulrike Schleicher; Otto S Wolfbeis; Christian Bogdan; Jonathan Jantsch
Journal:  J Invest Dermatol       Date:  2014-02-28       Impact factor: 8.551

4.  Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis.

Authors:  David F Ackart; Laurel Hascall-Dove; Silvia M Caceres; Natalie M Kirk; Brendan K Podell; Christian Melander; Ian M Orme; Jeff G Leid; Jerry A Nick; Randall J Basaraba
Journal:  Pathog Dis       Date:  2014-02-24       Impact factor: 3.166

5.  Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis.

Authors:  Hyungjin Eoh; Kyu Y Rhee
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-01       Impact factor: 11.205

6.  A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.

Authors:  Puiying A Mak; Srinivasa P S Rao; Mai Ping Tan; Xiuhua Lin; Jason Chyba; Joann Tay; Seow Hwee Ng; Bee Huat Tan; Joseph Cherian; Jeyaraj Duraiswamy; Pablo Bifani; Vivian Lim; Boon Heng Lee; Ngai Ling Ma; David Beer; Pamela Thayalan; Kelli Kuhen; Arnab Chatterjee; Frantisek Supek; Richard Glynne; Jun Zheng; Helena I Boshoff; Clifton E Barry; Thomas Dick; Kevin Pethe; Luis R Camacho
Journal:  ACS Chem Biol       Date:  2012-04-25       Impact factor: 5.100

Review 7.  Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis.

Authors:  Wenping Gong; Yan Liang; Xueqiong Wu
Journal:  Biomed Res Int       Date:  2020-01-02       Impact factor: 3.411

8.  Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence.

Authors:  Caitlin H Kowalski; Sarah R Beattie; Kevin K Fuller; Elizabeth A McGurk; Yi-Wei Tang; Tobias M Hohl; Joshua J Obar; Robert A Cramer
Journal:  mBio       Date:  2016-09-20       Impact factor: 7.867
  8 in total

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