Literature DB >> 21636301

Time-dependent changes in the plasma amino acid concentration in diabetes mellitus.

Taiga Mochida1, Takayuki Tanaka, Yasuko Shiraki, Hiroko Tajiri, Shirou Matsumoto, Kazutaka Shimbo, Toshihiko Ando, Kimitoshi Nakamura, Masahiro Okamoto, Fumio Endo.   

Abstract

We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21636301     DOI： 10.1016/j.ymgme.2011.05.002

Source DB:  PubMed          Journal:  Mol Genet Metab        ISSN： 1096-7192            Impact factor:   4.797


  17 in total

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