Literature DB >> 2163621

Dual effect of fluoride on phosphoinositide metabolism in rat brain cortex. Stimulation of phospholipase C and inhibition of polyphosphoinositide synthesis.

E Claro1, M A Wallace, J N Fain.   

Abstract

We have studied the effects of fluoride, guanosine 5'-[gamma-thio]triphosphate (GTP[S]) and carbachol on phospholipase C and polyphosphoinositide synthesis. The experimental system consisted of membranes from rat brain cortex, with exogenous [3H]phosphatidylinositol ([3H]PtdIns) as substrate. In such systems, we have not found evidence to support carbachol and/or GTP[S] stimulation of PtdIns phosphorylation. Fluoride inhibited synthesis of PtdIns4P and PtdIns(4,5)P2 from PtdIns. Consequently, under conditions where breakdown of polyphosphoinositides by phospholipase C was dependent on PtdIns kinase activity, fluoride inhibited activation by GTP[S] plus carbachol of phospholipase C. When conditions allowed direct breakdown of PtdIns and precluded PtdIns kinase activity, the stimulatory effects of fluoride and GTP[S] plus carbachol on phospholipase C activity were additive.

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Year:  1990        PMID： 2163621      PMCID： PMC1131501          DOI： 10.1042/bj2680733

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements.

Authors:  S J Taylor; J H Exton
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

2.  Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity.

Authors:  I Litosch
Journal:  Biochem J       Date:  1987-05-15       Impact factor: 3.857

3.  Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction.

Authors:  S Cockcroft; J A Taylor
Journal:  Biochem J       Date:  1987-01-15       Impact factor: 3.857

Review 4.  Inositol trisphosphate and diacylglycerol: two interacting second messengers.

Authors:  M J Berridge
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

5.  Polyphosphoinositide labeling in rat liver plasma membranes is reduced by preincubation with cholera toxin.

Authors:  M Biffen; B R Martin
Journal:  J Biol Chem       Date:  1987-06-05       Impact factor: 5.157

6.  Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery.

Authors:  T Sasaguri; M Hirata; H Kuriyama
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

7.  A phosphatidylinositol kinase in rat mast cell granules.

Authors:  M Kurosawa; C W Parker
Journal:  J Immunol       Date:  1986-01       Impact factor: 5.422

8.  Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

Authors:  P C Sternweis; A G Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

9.  The phosphatidylinositol kinase of rat brain.

Authors:  M Kai; G L White; J N Hawthorne
Journal:  Biochem J       Date:  1966-11       Impact factor: 3.857

10.  5-Methyltryptamine stimulates phospholipase C-mediated breakdown of exogenous phosphoinositides by blowfly salivary gland membranes.

Authors:  I Litosch; J N Fain
Journal:  J Biol Chem       Date:  1985-12-25       Impact factor: 5.157
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  5 in total

1.  Phospholipase C-beta 1 is regulated by a pertussis toxin-insensitive G-protein.

Authors:  T F Martin; J E Lewis; J A Kowalchyk
Journal:  Biochem J       Date:  1991-12-15       Impact factor: 3.857

Review 2.  Aluminum interaction with phosphoinositide-associated signal transduction.

Authors:  A Haug; B Shi; V Vitorello
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

3.  G-protein involvement in muscarinic receptor-stimulation of inositol phosphates in longitudinal smooth muscle from the small intestine of the guinea-pig.

Authors:  S A Prestwich; T B Bolton
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

4.  Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an "in vitro" model with synaptic endings from cerebral cortex and hippocampus.

Authors:  Sandra E Zulian; Mónica G Ilincheta de Boschero; Norma M Giusto
Journal:  Neurochem Res       Date:  2009-01-07       Impact factor: 3.996

5.  Stimulation of inositide degradation in clumping Stigmatella aurantiaca.

Authors:  M Benaïssa; J Vieyres-Lubochinsky; R Odéide; B Lubochinsky
Journal:  J Bacteriol       Date:  1994-03       Impact factor: 3.490
  5 in total

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