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Literature DB >> 2163617

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase.

Abstract

Database search using a bovine thymus ubiquitin C-terminal hydrolase sequence indicated 54% sequence identity with the abundant human neuron-specific protein gene product 9.5 (PGP9.5), which was then shown to possess the same activity [Wilkinson, Lee, Deshpande, Duerksen-Hughes, Boss & Pohl (1989) Science 246, 670-673]. A yeast counterpart of the enzyme is also known. The human PGP9.5 gene, described here, spans 10 kb, contains nine exons and displays 5' features some common to many genes and some common with neurofilament neuron-specific enolase and Thy-1-antigen gene 5' regions.

Entities: Gene Species

Mesh：

Substances：

Year: 1990 PMID： 2163617 PMCID： PMC1131465 DOI： 10.1042/bj2680521

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

26 in total

1. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.

Authors: K D Wilkinson; K M Lee; S Deshpande; P Duerksen-Hughes; J M Boss; J Pohl
Journal: Science Date: 1989-11-03 Impact factor: 47.728

2. Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

Authors: H Mori; J Kondo; Y Ihara
Journal: Science Date: 1987-03-27 Impact factor: 47.728

3. Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells.

Authors: I N Day; R J Thompson
Journal: FEBS Lett Date: 1987-01-05 Impact factor: 4.124

4. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.

Authors: M B Shapiro; P Senapathy
Journal: Nucleic Acids Res Date: 1987-09-11 Impact factor: 16.971

Review 5. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

Authors: M Kozak
Journal: Nucleic Acids Res Date: 1987-10-26 Impact factor: 16.971

6. Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein.

Authors: E Levy; R K Liem; P D'Eustachio; N J Cowan
Journal: Eur J Biochem Date: 1987-07-01

7. The structure and expression of neuron-specific enolase gene.

Authors: K Sakimura; E Kushiya; Y Takahashi; Y Suzuki
Journal: Gene Date: 1987 Impact factor: 3.688

8. Lambda ZAP: a bacteriophage lambda expression vector with in vivo excision properties.

Authors: J M Short; J M Fernandez; J A Sorge; W D Huse
Journal: Nucleic Acids Res Date: 1988-08-11 Impact factor: 16.971

9. The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it.

Authors: J F Lees; P S Shneidman; S F Skuntz; M J Carden; R A Lazzarini
Journal: EMBO J Date: 1988-07 Impact factor: 11.598

10. The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.

Authors: M W Myers; R A Lazzarini; V M Lee; W W Schlaepfer; D L Nelson
Journal: EMBO J Date: 1987-06 Impact factor: 11.598

15 in total

1. Rub1p processing by Yuh1p is required for wild-type levels of Rub1p conjugation to Cdc53p.

Authors: Bolan Linghu; Judy Callis; Mark G Goebl
Journal: Eukaryot Cell Date: 2002-06

2. New nucleotide sequence data on the EMBL File Server.

Authors:
Journal: Nucleic Acids Res Date: 1990-10-11 Impact factor: 16.971

3. Site-specific population dynamics and variable olfactory marker protein expression in the postnatal canine olfactory epithelium.

Authors: Patricia Bock; Karl Rohn; Andreas Beineke; Wolfgang Baumgärtner; Konstantin Wewetzer
Journal: J Anat Date: 2009-09-24 Impact factor: 2.610

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase.

1. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.

2. Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

3. Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells.

4. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.

Review 5. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

6. Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein.

7. The structure and expression of neuron-specific enolase gene.

8. Lambda ZAP: a bacteriophage lambda expression vector with in vivo excision properties.

9. The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it.

10. The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.

1. Rub1p processing by Yuh1p is required for wild-type levels of Rub1p conjugation to Cdc53p.

2. New nucleotide sequence data on the EMBL File Server.

3. Site-specific population dynamics and variable olfactory marker protein expression in the postnatal canine olfactory epithelium.

4. Porcine UCHL1: genomic organization, chromosome localization and expression analysis.

5. Reduced neurons in the ileum of proctocolectomized rat models.

6. Affinity purification and characterization of protein gene product 9.5 (PGP9.5) from retina.

7. Molecular structure of the human muscle-specific enolase gene (ENO3).

8. Target genes of neuron-restrictive silencer factor are abnormally up-regulated in human myotilinopathy.

Review 9. The ubiquitin-proteasome system in retinal health and disease.

10. Protein gene product 9.5 and ubiquitin immunoreactivities in rat epididymis epithelium.