Literature DB >> 21635555

Recurrent meningococcal sepsis in a presumptive immunocompetent host shown to be complement C5 deficient-a case report.

Gro Grimnes1, Hans Beckman, Knut Tore Lappegård, Tom Eirik Mollnes, Vegard Skogen.   

Abstract

Invasive meningococcal disease is a world wide challenge. Most cases occur in immunocompetent children and young adults, but some immunodeficiencies are linked to a greater risk of invasive neisserial infections. One of these is complement component deficiencies, particularly deficiency of properdin and the terminal complement components. We describe a case of recurrent meningococcal sepsis in a young man who was later diagnosed with complete lack of complement component C5. This case report emphasizes the need of having complement deficiencies in mind when being introduced to patients with invasive Neisseria-infections.
© 2011 The Authors. APMIS © 2011 APMIS.

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Year:  2011        PMID: 21635555     DOI: 10.1111/j.1600-0463.2011.02740.x

Source DB:  PubMed          Journal:  APMIS        ISSN: 0903-4641            Impact factor:   3.205


  4 in total

1.  Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release.

Authors:  Eivind O Samstad; Nathalie Niyonzima; Stig Nymo; Marie H Aune; Liv Ryan; Siril S Bakke; Knut T Lappegård; Ole-Lars Brekke; John D Lambris; Jan K Damås; Eicke Latz; Tom E Mollnes; Terje Espevik
Journal:  J Immunol       Date:  2014-02-19       Impact factor: 5.422

Review 2.  C5 complement deficiency in a Saudi family, molecular characterization of mutation and literature review.

Authors:  Rand Arnaout; Sahar Al Shorbaghi; Hasan Al Dhekri; Hamoud Al-Mousa; Abdulaziz Al Ghonaium; Bandar Al Saud; Saleh Al Muhsen; Lina Al Baik; Abbas Hawwari
Journal:  J Clin Immunol       Date:  2013-02-01       Impact factor: 8.317

Review 3.  Attending to warning signs of primary immunodeficiency diseases across the range of clinical practice.

Authors:  Beatriz Tavares Costa-Carvalho; Anete Sevciovic Grumach; José Luis Franco; Francisco Javier Espinosa-Rosales; Lily E Leiva; Alejandra King; Oscar Porras; Liliana Bezrodnik; Mathias Oleastro; Ricardo U Sorensen; Antonio Condino-Neto
Journal:  J Clin Immunol       Date:  2013-11-16       Impact factor: 8.317

4.  Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.

Authors:  A Landsem; H Fure; J Krey Ludviksen; D Christiansen; C Lau; M Mathisen; G Bergseth; S Nymo; K T Lappegård; T M Woodruff; T Espevik; T E Mollnes; O-L Brekke
Journal:  Clin Exp Immunol       Date:  2018-12-19       Impact factor: 4.330

  4 in total

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