| Literature DB >> 21635268 |
I A Wasfi1, W A Al Ali, B A Agha, A M Kamel, N A Al Biriki, K M Al Neaimi.
Abstract
The pharmacokinetics and metabolism of meloxicam was studied in camels (Camelus dromedarus) (n = 6) following intravenous (i.v.) administration of a dose of 0.6 mg·kg/body weight. The results obtained (mean ± SD) were as follows: the terminal elimination half-life (t(1/2β) ) was 40.2 ± 16.8 h and total body clearance (Cl(T) ) was 1.94 ± 0.66 mL·kg/h. The volume of distribution at steady state (V(SS)) was 92.8 ± 13.7 mL/kg. One metabolite of meloxicam was tentatively identified as methylhydroxy meloxicam. Meloxicam and metabolite were excreted unconjugated in urine. Meloxicam could be detected in plasma 10 days following i.v. administration in camels using a sensitive liquid chromatography tandem mass spectrometry (LC/MS/MS) method.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21635268 DOI： 10.1111/j.1365-2885.2011.01312.x
Source DB: PubMed Journal: J Vet Pharmacol Ther ISSN： 0140-7783 Impact factor: 1.786