Literature DB >> 2163366

Production of arachidonic acid metabolites by caprine alveolar macrophages.

M D Englen1, S M Taylor, W W Laegreid, R M Silflow, K L Banks, R Wes Leid.   

Abstract

The in vitro release of arachidonic acid (AA) metabolites from caprine alveolar macrophages (CAM) stimulated with the calcium ionophore A23187 or opsonized zymosan was examined. Leukotriene B4 [5(S),12(R)-6,14-cis-8,10-trans-dihydroxyeicosatetraenoic acid] was the major AA metabolite elicited with either agonist; smaller amounts of 12- and 5-mono-hydroxyeicosatetraenoic acid (HETE), and 12-hydroxyheptadecatrienoic acid (HHT) were also detected. Zymosan stimulation also caused the release of very small quantities of prostaglandins E2 and F2 alpha, and thromboxane B2. Our report is the first to describe arachidonic acid metabolism in CAM.

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Year:  1990        PMID： 2163366     DOI： 10.1007/BF00915808

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  14 in total

Review 1.  Secretory products of macrophages.

Authors:  C F Nathan
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808

Review 2.  In defense of the lung: paradoxical role of the pulmonary alveolar macrophage.

Authors:  H B Herscowitz
Journal:  Ann Allergy       Date:  1985-11

3.  Lipid composition of alveolar macrophage plasma membrane during postnatal development.

Authors:  M J Ricardo; G W Small; Q N Myrvik; L S Kucera
Journal:  J Immunol       Date:  1986-02-01       Impact factor: 5.422

4.  Stimulus-specific production of cyclooxygenase and lipoxygenase metabolites of arachidonic acid by bovine alveolar macrophages.

Authors:  W W Laegreid; S M Taylor; M D Englen; K M Straub; R M Silflow; H D Liggitt; R W Leid
Journal:  Inflammation       Date:  1989-04       Impact factor: 4.092

5.  Arachidonic acid metabolism in bovine alveolar macrophages. Effect of calcium ionophore on lipoxygenase products.

Authors:  S M Taylor; H D Liggitt; W W Laegreid; R Silflow; R W Leid
Journal:  Inflammation       Date:  1986-06       Impact factor: 4.092

6.  Reversal of virus-induced alveolar macrophage bactericidal dysfunction by cyclooxygenase inhibition in vitro.

Authors:  W W Laegreid; H D Liggitt; R M Silflow; J R Evermann; S M Taylor; R W Leid
Journal:  J Leukoc Biol       Date:  1989-04       Impact factor: 4.962

7.  Stimulation of arachidonic acid metabolism in silica-exposed alveolar macrophages.

Authors:  M D Englen; S M Taylor; W W Laegreid; H D Liggitt; R M Silflow; R G Breeze; R W Leid
Journal:  Exp Lung Res       Date:  1989-07       Impact factor: 2.459

Review 8.  Arachidonic acid metabolism and macrophage activation.

Authors:  S W Chensue; S L Kunkel
Journal:  Clin Lab Med       Date:  1983-12       Impact factor: 1.935

9.  Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography.

Authors:  G M Patton; J M Fasulo; S J Robins
Journal:  J Lipid Res       Date:  1982-01       Impact factor: 5.922

10.  Bovine pulmonary alveolar macrophages: antemortem recovery and in vitro evaluation of bacterial phagocytosis and killing.

Authors:  E Trigo; H D Liggitt; R G Breeze; R W Leid; R M Silflow
Journal:  Am J Vet Res       Date:  1984-09       Impact factor: 1.156
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