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Literature DB >> 216336

Reversible inhibition of the induction of DNA polymerase of herpes simplex virus type 2 in HeLa cells.

Abstract

The induction of DNA polymerase of herpes simplex virus type 2 in HeLa cells was inhibited by 2-mercapto-1-(beta-4-pyridethyl)benzimidazole added at an early time after infection. However, the inhibitory effect was easily released by removal of the inhibitor. Since the drug disorganizes nucleolar structure and prevents its function in HeLa cells in a reversible manner, it is possible that nucleoli are involved in the induction of DNA polymerase of this virus.

Entities: Chemical Species

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Year: 1978 PMID： 216336 DOI： 10.1007/bf01317825

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

15 in total

1. Inhibitory action of 2-mercapto-1-(beta-4-pyridethyl)benzimidazole on viral neuraminidase synthesis in HeLa cells infected with myxoviruses.

Authors: H Nishigori; C Nishimura
Journal: Chem Pharm Bull (Tokyo) Date: 1975-08 Impact factor: 1.645

2. DNA polymerase induction by DNA-negative temperature-sensitive mutants of herpes simplex virus type 2.

Authors: D J Purifoy; M Benyesh-Melnick
Journal: Virology Date: 1975-12 Impact factor: 3.616

3. The alteration of ribosomes for mRNA selection concerned with adenovirus growth in SV40-infected simian cells.

Authors: K Nakajima; K Oda
Journal: Virology Date: 1975-09 Impact factor: 3.616

4. Induction of deoxyribonucleic acid polymerase and deoxyribonuclease activities in cells infected with herpes simplex virus type II.

Authors: J Hay; H Moss; I W Halliburton
Journal: Biochem J Date: 1971-10 Impact factor: 3.857

5. Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus.

Authors: H M Keir; J Hay; J M Morrison; H Subak-Sharpe
Journal: Nature Date: 1966-04-23 Impact factor: 49.962

Reversible inhibition of the induction of DNA polymerase of herpes simplex virus type 2 in HeLa cells.

1. Inhibitory action of 2-mercapto-1-(beta-4-pyridethyl)benzimidazole on viral neuraminidase synthesis in HeLa cells infected with myxoviruses.

2. DNA polymerase induction by DNA-negative temperature-sensitive mutants of herpes simplex virus type 2.

3. The alteration of ribosomes for mRNA selection concerned with adenovirus growth in SV40-infected simian cells.

4. Induction of deoxyribonucleic acid polymerase and deoxyribonuclease activities in cells infected with herpes simplex virus type II.

5. Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus.

6. Morphologic and metabolic alterations in hepatic cell nucleoli induced by varying doses of actinomycin D.

7. Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.

Review 8. Antiviral drugs. Mode of action and chemotherapy of viral infections of man.

9. A reversible inhibitor of nucleic acid synthesis.

1. Teratogenicity of methyl benzimidazole carbamate in rats and rabbits.