Literature DB >> 21632983

Rituximab's new therapeutic target: the podocyte actin cytoskeleton.

Andrew C Chan1.   

Abstract

Therapeutic off-target activities are well recognized for small-molecule drugs. In contrast, monoclonal antibodies (mAbs) traditionally are believed to act specifically and lack off-target therapeutic effects. In this issue of Science Translational Medicine, Fornoni et al. show therapeutic benefit, through an off-target-mediated mechanism, of the mAb drug rituximab in recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation. These data shed new light on FSGS pathogenesis and suggest new therapeutic interventions for proteinuric diseases.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21632983     DOI： 10.1126/scitranslmed.3002429

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  6 in total

1.  Refractory focal segmental glomerulosclerosis in the adult: complete and sustained remissions of two episodes of nephrotic syndrome after a single dose of rituximab.

Authors:  Maddalena Marasà; Paolo Cravedi; Barbara Ruggiero; Piero Ruggenenti
Journal:  BMJ Case Rep       Date:  2014-08-25

2.  Targeted therapies: Is there a role for rituximab in nephrotic syndrome?

Authors:  John Feehally
Journal:  Nat Rev Nephrol       Date:  2014-03-11       Impact factor: 28.314

Review 3.  Childhood nephrotic syndrome--current and future therapies.

Authors:  Larry A Greenbaum; Rainer Benndorf; William E Smoyer
Journal:  Nat Rev Nephrol       Date:  2012-06-12       Impact factor: 28.314

4.  Different effects of rituximab on a native kidney and a post-transplant kidney with recurrence of focal segmental glomerulosclerosis.

Authors:  Ayami Ino; Segawa Kaori; Takashi Takei; Kosaku Nitta
Journal:  CEN Case Rep       Date:  2020-01-30

5.  Actin-associated Proteins in the Pathogenesis of Podocyte Injury.

Authors:  Fang-Fang He; Shan Chen; Hua Su; Xian-Fang Meng; Chun Zhang
Journal:  Curr Genomics       Date:  2013-11       Impact factor: 2.236

6.  Resemblance-Ranking Peptide Library to Screen for Binders to Antibodies on a Peptidomic Scale.

Authors:  Felix Jenne; Sergey Biniaminov; Nathalie Biniaminov; Philipp Marquardt; Clemens von Bojničić-Kninski; Roman Popov; Anja Seckinger; Dirk Hose; Alexander Nesterov-Mueller
Journal:  Int J Mol Sci       Date:  2022-03-23       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.