CONTEXT: Adiponectin, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations may be important in the pathophysiology of cardiovascular disease. OBJECTIVE: We tested the hypothesis that serum adiponectin rather than insulin differs from early life, between South Asians and Europeans, with a potentially key role in excess cardiovascular risk characteristic of adult South Asians. DESIGN AND PARTICIPANTS: We conducted a longitudinal study of 215 British-born children of European (n = 138) and South Asian (n = 77) origin, from birth to 3 yr. MAIN OUTCOME MEASURE: Serum adiponectin, insulin, proinsulin and HDL-C concentrations were assessed in relation to ethnic group and growth in anthropometric variables from 0-3 yr of age. RESULTS: Serum adiponectin was lower in South Asian children, despite their smaller size, notable at age 3-6 months (9.5 vs. 11.8 mg/liter; P = 0.04), with no ethnic differences in serum lipids or insulin or proinsulin. In mixed-effects longitudinal models for HDL-C, determinants were adiponectin (P = 0.034), age (P < 0.001), and body mass index (P < 0.001) but not ethnicity. None of these or growth variables affected either insulin or proinsulin. In a fully adjusted mixed-effects longitudinal model including age, sex, insulin, and proinsulin, the independent determinants of serum adiponectin were height [21.3 (95% confidence interval = 31.7-10.8 cm lower, for every 1 mmol/liter increase in adiponectin, P < 0.001], HDL-C [2.8 (1.3-4.2) mmol/liter higher, P < 0.0001], body mass index (lower, P = 0.03), and South Asian ethnicity (lower, P = 0.01). CONCLUSIONS: These British South Asian-origin infants have lower serum adiponectin but no differences in HDL-C or insulin molecules. In South Asians, factors affecting adiponectin metabolism in early life, rather than insulin resistance, likely determine later excess cardiovascular risk.
CONTEXT: Adiponectin, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations may be important in the pathophysiology of cardiovascular disease. OBJECTIVE: We tested the hypothesis that serum adiponectin rather than insulin differs from early life, between South Asians and Europeans, with a potentially key role in excess cardiovascular risk characteristic of adult South Asians. DESIGN AND PARTICIPANTS: We conducted a longitudinal study of 215 British-born children of European (n = 138) and South Asian (n = 77) origin, from birth to 3 yr. MAIN OUTCOME MEASURE: Serum adiponectin, insulin, proinsulin and HDL-C concentrations were assessed in relation to ethnic group and growth in anthropometric variables from 0-3 yr of age. RESULTS: Serum adiponectin was lower in South Asian children, despite their smaller size, notable at age 3-6 months (9.5 vs. 11.8 mg/liter; P = 0.04), with no ethnic differences in serum lipids or insulin or proinsulin. In mixed-effects longitudinal models for HDL-C, determinants were adiponectin (P = 0.034), age (P < 0.001), and body mass index (P < 0.001) but not ethnicity. None of these or growth variables affected either insulin or proinsulin. In a fully adjusted mixed-effects longitudinal model including age, sex, insulin, and proinsulin, the independent determinants of serum adiponectin were height [21.3 (95% confidence interval = 31.7-10.8 cm lower, for every 1 mmol/liter increase in adiponectin, P < 0.001], HDL-C [2.8 (1.3-4.2) mmol/liter higher, P < 0.0001], body mass index (lower, P = 0.03), and South Asian ethnicity (lower, P = 0.01). CONCLUSIONS: These British South Asian-origin infants have lower serum adiponectin but no differences in HDL-C or insulin molecules. In South Asians, factors affecting adiponectin metabolism in early life, rather than insulin resistance, likely determine later excess cardiovascular risk.
Authors: C S Yajnik; H G Lubree; S S Rege; S S Naik; J A Deshpande; S S Deshpande; C V Joglekar; J S Yudkin Journal: J Clin Endocrinol Metab Date: 2002-12 Impact factor: 5.958
Authors: Shirya Rashid; P Hugh R Barrett; Kristine D Uffelman; Takehiko Watanabe; Khosrow Adeli; Gary F Lewis Journal: Arterioscler Thromb Vasc Biol Date: 2002-03-01 Impact factor: 8.311
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Authors: N Ouchi; S Kihara; Y Arita; M Nishida; A Matsuyama; Y Okamoto; M Ishigami; H Kuriyama; K Kishida; H Nishizawa; K Hotta; M Muraguchi; Y Ohmoto; S Yamashita; T Funahashi; Y Matsuzawa Journal: Circulation Date: 2001-02-27 Impact factor: 29.690
Authors: S S Anand; S Yusuf; V Vuksan; S Devanesen; K K Teo; P A Montague; L Kelemen; C Yi; E Lonn; H Gerstein; R A Hegele; M McQueen Journal: Lancet Date: 2000-07-22 Impact factor: 79.321
Authors: Robert S Lindsay; Tohru Funahashi; Robert L Hanson; Yuji Matsuzawa; Sachiyo Tanaka; P Antonio Tataranni; William C Knowler; Jonathan Krakoff Journal: Lancet Date: 2002-07-06 Impact factor: 79.321
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Authors: Seeromanie Harding; Maria João Silva; Oarabile R Molaodi; Zinat E Enayat; Aidan Cassidy; Alexis Karamanos; Ursula M Read; J Kennedy Cruickshank Journal: BMJ Open Date: 2016-12-14 Impact factor: 2.692
Authors: G V Ramesh Prasad; Leon Vorobeichik; Michelle M Nash; Michael Huang; Lindita Rapi; Graham Maguire; Muhammad Mamdani; Andrew T Yan; Philip W Connelly Journal: Clin Kidney J Date: 2012-04
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