INTRODUCTION: Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology. MATERIALS AND METHODS: Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions. RESULTS: 24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (0%) stained (p = 0.0000784). 35 of 39 (90%) adenocarcinomas stained for GPR30, while only 4 of 15 (27%) non-carcinomas stained (p = 0.0000036). Apart from stromal staining in one case of mucinous cystic neoplasm, no cases stained for ER. 27 of 37 (73%) adenocarcinoma fine needle aspirates were positive for mesothelin. DISCUSSION: GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions.
INTRODUCTION: Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology. MATERIALS AND METHODS: Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions. RESULTS: 24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (0%) stained (p = 0.0000784). 35 of 39 (90%) adenocarcinomas stained for GPR30, while only 4 of 15 (27%) non-carcinomas stained (p = 0.0000036). Apart from stromal staining in one case of mucinous cystic neoplasm, no cases stained for ER. 27 of 37 (73%) adenocarcinoma fine needle aspirates were positive for mesothelin. DISCUSSION: GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions.
Authors: Tapan K Nayak; Chinnasamy Ramesh; Helen J Hathaway; Jeffrey P Norenberg; Jeffrey B Arterburn; Eric R Prossnitz Journal: Mol Cancer Res Date: 2014-07-16 Impact factor: 5.852
Authors: Kun Wang; Vidya Bodempudi; Zhengian Liu; Emma Borrego-Diaz; Farnaz Yamoutpoor; Anna Meyer; Richard A Woo; Weihong Pan; Arkadiusz Z Dudek; Mojtaba S Olyaee; Tuba Esfandyari; Faris Farassati Journal: PLoS One Date: 2012-04-02 Impact factor: 3.240
Authors: Whitney K Petrie; Megan K Dennis; Chelin Hu; Donghai Dai; Jeffrey B Arterburn; Harriet O Smith; Helen J Hathaway; Eric R Prossnitz Journal: Obstet Gynecol Int Date: 2013-11-27
Authors: Gary Tozbikian; Edi Brogi; Kyuichi Kadota; Jeffrey Catalano; Muzaffar Akram; Sujata Patil; Alice Y Ho; Jorge S Reis-Filho; Britta Weigelt; Larry Norton; Prasad S Adusumilli; Hannah Yong Wen Journal: PLoS One Date: 2014-12-15 Impact factor: 3.240