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Literature DB >> 21632254

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

Keefe T Chan¹, Sarah J Creed, James E Bear.

Abstract

Coronins are a conserved family of actin cytoskeleton regulators that promote cell motility and modulate other actin-dependent processes. Although these proteins have been known for 20 years, substantial progress has been made in the past 5 years towards their understanding. In this review, we examine this progress, place it into the context of what was already known, and pose several questions that remain to be addressed. In particular, we cover the emerging consensus about the role of Type I coronins in coordinating the function of Arp2/3 complex and ADF/cofilin proteins. This coordination plays an important role in leading-edge actin dynamics and overall cell motility. Finally, we discuss the roles played by the more exotic coronins of the Type II and III classes in cellular processes away from the leading edge.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2011 PMID： 21632254 PMCID： PMC3163407 DOI： 10.1016/j.tcb.2011.04.004

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

57 in total

1. Functional surfaces on the actin-binding protein coronin revealed by systematic mutagenesis.

Authors: Meghal Gandhi; Mohini Jangi; Bruce L Goode
Journal: J Biol Chem Date: 2010-09-02 Impact factor: 5.157

2. Redundant and unique roles of coronin proteins in Dictyostelium.

Authors: Maria C Shina; Annette Müller-Taubenberger; Can Unal; Michael Schleicher; Michael Steinert; Ludwig Eichinger; Rolf Müller; Rosemarie Blau-Wasser; Gernot Glöckner; Angelika A Noegel
Journal: Cell Mol Life Sci Date: 2010-07-18 Impact factor: 9.261

3. Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation.

Authors: Philipp Mueller; Xiaolong Liu; Jean Pieters
Journal: J Immunol Date: 2011-02-21 Impact factor: 5.422

4. The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans.

Authors: C A Rappleye; A R Paredez; C W Smith; K L McDonald; R V Aroian
Journal: Genes Dev Date: 1999-11-01 Impact factor: 11.361

5. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.

Authors: A M Weaver; A V Karginov; A W Kinley; S A Weed; Y Li; J T Parsons; J A Cooper
Journal: Curr Biol Date: 2001-03-06 Impact factor: 10.834

6. Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin.

Authors: Su-Ling Liu; Karen M Needham; Jordan R May; Brad J Nolen
Journal: J Biol Chem Date: 2011-03-21 Impact factor: 5.157

7. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus.

Authors: Ziqiang Spoerl; Maria Stumpf; Angelika A Noegel; Andreas Hasse
Journal: J Biol Chem Date: 2002-10-10 Impact factor: 5.157

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

1. Functional surfaces on the actin-binding protein coronin revealed by systematic mutagenesis.

2. Redundant and unique roles of coronin proteins in Dictyostelium.

3. Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation.

4. The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans.

5. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.

6. Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin.

7. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus.

Review 8. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells.

9. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.

10. Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin.

1. Rac1 activation comes full circle.

2. Isoform diversity in the Arp2/3 complex determines actin filament dynamics.

Review 3. Coronin-1A: immune deficiency in humans and mice.

4. Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.

Review 5. Imprinted and X-linked non-coding RNAs as potential regulators of human placental function.

6. Altered expression of neuroplasticity-related genes in the brain of depressed suicides.

Review 7. Emergent Role of Coronin-1a in Neuronal Signaling.

Review 8. The expanding spectrum of human coronin 1A deficiency.

9. Minimal amino acids in the I/LWEQ domain required for anterior/posterior localization in Dictyostelium.

Review 10. Global treadmilling coordinates actin turnover and controls the size of actin networks.