Ty S Schepis1, Jahn K Hakes. 1. Department of Psychology, Texas State University, 601 University Drive, San Marcos, TX 78666, USA. schepis@txstate.edu
Abstract
AIMS: Given the rising rates of the non-medical use of prescription medications (NUPM) and strong cross-sectional associations between psychopathology and NUPM, we examined whether a history of NUPM increased the risk for onset and recurrence of psychopathology. DESIGN: Longitudinal data are from waves 1 and 2 of the National Epidemiological Survey on Alcoholism and Related Conditions (NESARC). SETTING: The NESARC is a nation-wide, household-based survey. PARTICIPANTS: A total of 34,653 US resident participants who completed both NESARC waves were included in analyses. MEASUREMENTS: Primary measures were history of NUPM and Axis I psychopathology at wave 1. Wave 1 personality disorder diagnosis and sociodemographic characteristics were used as control variables. FINDINGS: Design-based logistic regression analyses indicated that life-time and past year NUPM at wave 1 increased risk for onset of psychopathology among those with no history of psychopathology at baseline, with particular risk for non-NUPM substance use and bipolar disorders. Life-time and past year NUPM were associated with recurrence of alcohol and non-NUPM substance use disorders among those with these diagnoses at baseline. In contrast, life-time and past year NUPM was associated with the onset of all examined disorders among those with a different diagnosis at baseline. CONCLUSIONS: Non-medical use of prescription medications is a consistent risk factor for the onset and recurrence of psychopathology.
AIMS: Given the rising rates of the non-medical use of prescription medications (NUPM) and strong cross-sectional associations between psychopathology and NUPM, we examined whether a history of NUPM increased the risk for onset and recurrence of psychopathology. DESIGN: Longitudinal data are from waves 1 and 2 of the National Epidemiological Survey on Alcoholism and Related Conditions (NESARC). SETTING: The NESARC is a nation-wide, household-based survey. PARTICIPANTS: A total of 34,653 US resident participants who completed both NESARC waves were included in analyses. MEASUREMENTS: Primary measures were history of NUPM and Axis I psychopathology at wave 1. Wave 1personality disorder diagnosis and sociodemographic characteristics were used as control variables. FINDINGS: Design-based logistic regression analyses indicated that life-time and past year NUPM at wave 1 increased risk for onset of psychopathology among those with no history of psychopathology at baseline, with particular risk for non-NUPM substance use and bipolar disorders. Life-time and past year NUPM were associated with recurrence of alcohol and non-NUPM substance use disorders among those with these diagnoses at baseline. In contrast, life-time and past year NUPM was associated with the onset of all examined disorders among those with a different diagnosis at baseline. CONCLUSIONS: Non-medical use of prescription medications is a consistent risk factor for the onset and recurrence of psychopathology.
Authors: Laura P Richardson; Joan E Russo; Wayne Katon; Carolyn A McCarty; Andrea DeVries; Mark J Edlund; Bradley C Martin; Mark Sullivan Journal: J Adolesc Health Date: 2012-02-28 Impact factor: 5.012
Authors: Carolyn F Wong; Karol Silva; Aleksandar Kecojevic; Sheree M Schrager; Jennifer Jackson Bloom; Ellen Iverson; Stephen E Lankenau Journal: Drug Alcohol Depend Date: 2013-02-28 Impact factor: 4.492