Literature DB >> 2163126

Lithium hydroxide/aqueous methanol: mild reagent for the hydrolysis of bile acid methyl esters.

B Dayal1, G Salen, B Toome, G S Tint, S Shefer, J Padia.   

Abstract

An efficient and convenient procedure for the hydrolysis of bile acid methyl esters is described. This is achieved by the addition of aqueous lithium hydroxide in methanol/dioxane (or tetrahydrofuran) at room temperature. Under these conditions, the formates as well as the acetate derivatives were also hydrolyzed, and the desired bile acids were isolated in 86 to 94% yield.

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Year:  1990        PMID： 2163126     DOI： 10.1016/0039-128x(90)90021-3

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  5 in total

1.  Rational design of potent, small, synthetic allosteric inhibitors of thrombin.

Authors:  Preetpal Singh Sidhu; Aiye Liang; Akul Y Mehta; May H Abdel Aziz; Qibing Zhou; Umesh R Desai
Journal:  J Med Chem       Date:  2011-07-18       Impact factor: 7.446

2.  The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile.

Authors:  Shiv K Sharma; Christopher Yip; Emilio Xavier Esposito; Prateek V Sharma; Matthew P Simon; Ernesto Abel-Santos; Steven M Firestine
Journal:  J Med Chem       Date:  2018-07-30       Impact factor: 7.446

3.  Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study.

Authors:  Uttara Soumyanarayanan; Varadaraj G Bhat; Sidhartha S Kar; Jesil A Mathew
Journal:  Org Med Chem Lett       Date:  2012-06-12

4.  Reversible on-surface wiring of resistive circuits.

Authors:  Michael S Inkpen; Yann R Leroux; Philippe Hapiot; Luis M Campos; Latha Venkataraman
Journal:  Chem Sci       Date:  2017-04-07       Impact factor: 9.825

5.  Synthesis and Characterization of Telmisartan-Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia.

Authors:  Anna M Schoepf; Stefan Salcher; Verena Hohn; Florina Veider; Petra Obexer; Ronald Gust
Journal:  ChemMedChem       Date:  2020-05-06       Impact factor: 3.466
  5 in total

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