OBJECTIVE: To evaluate mannose-binding lectin (MBL) serum levels as a marker for predicting sepsis, septic shock, and their outcomes in neonates. PATIENTS AND METHODS: A prospective study was conducted on 62 neonates (27 preterm and 35 full term) with culture-proven sepsis and 35 controls. Serum levels of MBL were measured by immunoassay. RESULTS: Of 62 infants with positive blood cultures (Gram-negative = 44 and Gram-positive = 18), 11 infants had severe sepsis and 6 neonates developed septic shock. MBL levels were significantly lower in infants with sepsis than in control group (0.39 ± 0.07 vs. 1.34 ± 0.03 μg/ml; p < 0.001). The lowest MBL levels were detected in those infants with septic shock, particularly those who died (p < 0.05). MBL had high sensitivity (96.7), specificity (97.1), positive (98.3), and negative (94.4) predictive values to detect sepsis. CONCLUSION: Low MBL serum levels could be considered as sensitive and specific marker for predicting sepsis, septic shock, and their clinical outcomes in newborn infants.
OBJECTIVE: To evaluate mannose-binding lectin (MBL) serum levels as a marker for predicting sepsis, septic shock, and their outcomes in neonates. PATIENTS AND METHODS: A prospective study was conducted on 62 neonates (27 preterm and 35 full term) with culture-proven sepsis and 35 controls. Serum levels of MBL were measured by immunoassay. RESULTS: Of 62 infants with positive blood cultures (Gram-negative = 44 and Gram-positive = 18), 11 infants had severe sepsis and 6 neonates developed septic shock. MBL levels were significantly lower in infants with sepsis than in control group (0.39 ± 0.07 vs. 1.34 ± 0.03 μg/ml; p < 0.001). The lowest MBL levels were detected in those infants with septic shock, particularly those who died (p < 0.05). MBL had high sensitivity (96.7), specificity (97.1), positive (98.3), and negative (94.4) predictive values to detect sepsis. CONCLUSION: Low MBL serum levels could be considered as sensitive and specific marker for predicting sepsis, septic shock, and their clinical outcomes in newborn infants.
Authors: Iliana Bersani; Cinzia Auriti; Maria Paola Ronchetti; Giusi Prencipe; Diego Gazzolo; Andrea Dotta Journal: Biomed Res Int Date: 2015-01-18 Impact factor: 3.411
Authors: Thor A Wagner; Courtney A Gravett; Sara Healy; Viju Soma; Janna C Patterson; Michael G Gravett; Craig E Rubens Journal: J Glob Health Date: 2011-12 Impact factor: 4.413