Literature DB >> 21631125

The methylation effect in medicinal chemistry.

Eliezer J Barreiro1, Arthur E Kümmerle, Carlos A M Fraga.   

Abstract

Mesh：

Substances：

Year:  2011        PMID： 21631125     DOI： 10.1021/cr200060g

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


× No keyword cloud information.
  79 in total

1.  Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).

Authors:  Pauline W Ondachi; Chad M Kormos; Scott P Runyon; James B Thomas; S Wayne Mascarella; Ann M Decker; Hernán A Navarro; Timothy R Fennell; Rodney W Snyder; F Ivy Carroll
Journal:  J Med Chem       Date:  2018-08-29       Impact factor: 7.446

2.  Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters.

Authors:  Alexander M Haydl; John F Hartwig
Journal:  Org Lett       Date:  2019-02-14       Impact factor: 6.005

3.  Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source.

Authors:  Stavros K Kariofillis; Benjamin J Shields; Makeda A Tekle-Smith; Michael J Zacuto; Abigail G Doyle
Journal:  J Am Chem Soc       Date:  2020-04-10       Impact factor: 15.419

4.  Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.

Authors:  Aswini Kumar Giri; Christopher R Apostol; Yue Wang; Brittany L Forte; Tally M Largent-Milnes; Peg Davis; David Rankin; Gabriella Molnar; Keith M Olson; Frank Porreca; Todd W Vanderah; Victor J Hruby
Journal:  J Med Chem       Date:  2015-10-30       Impact factor: 7.446

5.  Palladium/Norbornene Cooperative Catalysis.

Authors:  Jianchun Wang; Guangbin Dong
Journal:  Chem Rev       Date:  2019-04-25       Impact factor: 60.622

6.  Trimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters.

Authors:  Zhi-Tao He; Haoquan Li; Alexander M Haydl; Gregory T Whiteker; John F Hartwig
Journal:  J Am Chem Soc       Date:  2018-11-28       Impact factor: 15.419

7.  Methyl effects on protein-ligand binding.

Authors:  Cheryl S Leung; Siegfried S F Leung; Julian Tirado-Rives; William L Jorgensen
Journal:  J Med Chem       Date:  2012-04-23       Impact factor: 7.446

8.  Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction.

Authors:  Zuyuan Shen; Shilei Zhang; Huihui Geng; Jiarui Wang; Xinyu Zhang; Anqi Zhou; Cheng Yao; Xiaobei Chen; Wei Wang
Journal:  Org Lett       Date:  2019-01-07       Impact factor: 6.005

9.  Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).

Authors:  Chad M Kormos; Pauline W Ondachi; Scott P Runyon; James B Thomas; S Wayne Mascarella; Ann M Decker; Hernán A Navarro; Timothy R Fennell; Rodney W Snyder; F Ivy Carroll
Journal:  J Med Chem       Date:  2018-08-29       Impact factor: 7.446

10.  Late-stage oxidative C(sp3)-H methylation.

Authors:  Kaibo Feng; Raundi E Quevedo; Jeffrey T Kohrt; Martins S Oderinde; Usa Reilly; M Christina White
Journal:  Nature       Date:  2020-03-16       Impact factor: 49.962
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.