Literature DB >> 21630414

Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes.

Hakon Hakonarson1, Struan F A Grant.   

Abstract

It has proven to be challenging to isolate the genes underlying the genetic components conferring susceptibility to type 1 and type 2 diabetes. Unlike previous approaches, 'genome-wide association studies' have extensively delivered on the promise of uncovering genetic determinants of complex diseases, with a number of novel disease-associated variants being largely replicated by independent groups. This review provides an overview of these recent breakthroughs in the context of type 1 and type 2 diabetes, and outlines strategies on how these findings will be applied to impact clinical care for these two highly prevalent disorders.
Copyright © 2011 John Wiley & Sons, Ltd.

Entities:  

Keywords:  diabetes; genetics; genome-wide association studies

Mesh：

Year:  2011        PMID： 21630414     DOI： 10.1002/dmrr.1221

Source DB:  PubMed          Journal:  Diabetes Metab Res Rev        ISSN： 1520-7552            Impact factor:   4.876


  12 in total

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Authors:  Mairi H McLean; Dario Dieguez; Lindsey M Miller; Howard A Young
Journal:  Gut       Date:  2014-11-21       Impact factor: 23.059

2.  An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.

Authors:  Poonam R Sharma; Aaron J Mackey; Eden A Dejene; James W Ramadan; Carl D Langefeld; Nicholette D Palmer; Kent D Taylor; Lynne E Wagenknecht; Richard M Watanabe; Stephen S Rich; Craig S Nunemaker
Journal:  Endocrinology       Date:  2015-05-27       Impact factor: 4.736

3.  A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Authors:  Andrea D Coviello; Robin Haring; Melissa Wellons; Dhananjay Vaidya; Terho Lehtimäki; Sarah Keildson; Kathryn L Lunetta; Chunyan He; Myriam Fornage; Vasiliki Lagou; Massimo Mangino; N Charlotte Onland-Moret; Brian Chen; Joel Eriksson; Melissa Garcia; Yong Mei Liu; Annemarie Koster; Kurt Lohman; Leo-Pekka Lyytikäinen; Ann-Kristin Petersen; Jennifer Prescott; Lisette Stolk; Liesbeth Vandenput; Andrew R Wood; Wei Vivian Zhuang; Aimo Ruokonen; Anna-Liisa Hartikainen; Anneli Pouta; Stefania Bandinelli; Reiner Biffar; Georg Brabant; David G Cox; Yuhui Chen; Steven Cummings; Luigi Ferrucci; Marc J Gunter; Susan E Hankinson; Hannu Martikainen; Albert Hofman; Georg Homuth; Thomas Illig; John-Olov Jansson; Andrew D Johnson; David Karasik; Magnus Karlsson; Johannes Kettunen; Douglas P Kiel; Peter Kraft; Jingmin Liu; Östen Ljunggren; Mattias Lorentzon; Marcello Maggio; Marcello R P Markus; Dan Mellström; Iva Miljkovic; Daniel Mirel; Sarah Nelson; Laure Morin Papunen; Petra H M Peeters; Inga Prokopenko; Leslie Raffel; Martin Reincke; Alex P Reiner; Kathryn Rexrode; Fernando Rivadeneira; Stephen M Schwartz; David Siscovick; Nicole Soranzo; Doris Stöckl; Shelley Tworoger; André G Uitterlinden; Carla H van Gils; Ramachandran S Vasan; H-Erich Wichmann; Guangju Zhai; Shalender Bhasin; Martin Bidlingmaier; Stephen J Chanock; Immaculata De Vivo; Tamara B Harris; David J Hunter; Mika Kähönen; Simin Liu; Pamela Ouyang; Tim D Spector; Yvonne T van der Schouw; Jorma Viikari; Henri Wallaschofski; Mark I McCarthy; Timothy M Frayling; Anna Murray; Steve Franks; Marjo-Riitta Järvelin; Frank H de Jong; Olli Raitakari; Alexander Teumer; Claes Ohlsson; Joanne M Murabito; John R B Perry
Journal:  PLoS Genet       Date:  2012-07-19       Impact factor: 5.917

4.  The genomic signature of trait-associated variants.

Authors:  Alida S D Kindt; Pau Navarro; Colin A M Semple; Chris S Haley
Journal:  BMC Genomics       Date:  2013-02-18       Impact factor: 3.969

5.  Stem cell approaches for diabetes: towards beta cell replacement.

Authors:  Gordon C Weir; Claudia Cavelti-Weder; Susan Bonner-Weir
Journal:  Genome Med       Date:  2011-09-27       Impact factor: 11.117

Review 6.  Genetics of type 2 diabetes-pitfalls and possibilities.

Authors:  Rashmi B Prasad; Leif Groop
Journal:  Genes (Basel)       Date:  2015-03-12       Impact factor: 4.096

7.  Complex disease interventions from a network model for type 2 diabetes.

Authors:  Deniz Rende; Nihat Baysal; Betul Kirdar
Journal:  PLoS One       Date:  2013-06-11       Impact factor: 3.240

8.  Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

Authors:  Anthony G Comuzzie; Shelley A Cole; Sandra L Laston; V Saroja Voruganti; Karin Haack; Richard A Gibbs; Nancy F Butte
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240

9.  Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation.

Authors:  Adriane F Evangelista; Cristhianna V A Collares; Danilo J Xavier; Claudia Macedo; Fernanda S Manoel-Caetano; Diane M Rassi; Maria C Foss-Freitas; Milton C Foss; Elza T Sakamoto-Hojo; Catherine Nguyen; Denis Puthier; Geraldo A Passos; Eduardo A Donadi
Journal:  BMC Med Genomics       Date:  2014-05-23       Impact factor: 3.063

10.  T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders.

Authors:  Jyoti Rani; Inna Mittal; Atreyi Pramanik; Namita Singh; Namita Dube; Smriti Sharma; Bhanwar Lal Puniya; Muthukurussi Varieth Raghunandanan; Ahmed Mobeen; Srinivasan Ramachandran
Journal:  Sci Rep       Date:  2017-07-31       Impact factor: 4.379
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