R P Agrawal1, S Jain, S Shah, A Chopra, V Agarwal. 1. Department of Medicine, Diabetes Care & Research Centre, SP Medical College, Bikaner, Rajasthan, India. drrpagrawal@yahoo.co.in
Abstract
BACKGROUND/ OBJECTIVES:Hypoglycemic effect of camel milk supplementation in experimental rat model and significant reduction in doses of insulin in type 1 diabetic patients have been observed in our previous studies. This long-term study was undertaken to assess the efficacy, safety and acceptability of camel milk as an adjunct to insulin therapy in type 1 diabetics. SUBJECTS/ METHODS: In this 2-year randomized clinical, parallel design study, 24 type 1 diabetics were enrolled and divided into two groups. Group I (n=12) received usual care, that is, diet, exercise and insulin and Group II (n=12) received 500 ml camel milk in addition to the usual care. Insulin requirement was titrated weekly by blood glucose estimation. Results were analyzed by using the regression technique. RESULTS: In camel milk group, there was decrease in mean blood glucose (118.58±19-93.16±17.06 mg/dl), hemoglobin A1c levels (7.81±1.39-5.44±0.81%) and insulin doses (32.50±9.99-17.50±12.09 U/day, P<0.05). Out of 12 subjects receiving camel milk, insulin requirement in 3 subjects reduced to zero. There was nonsignificant change in plasma insulin and anti-insulin antibodies in both the groups. CONCLUSION: It may be stated that camel milk is safe and efficacious in improving long-term glycemic control, with a significant reduction in the doses of insulin in type 1 diabetic patients.
RCT Entities:
BACKGROUND/ OBJECTIVES: Hypoglycemic effect of camel milk supplementation in experimental rat model and significant reduction in doses of insulin in type 1 diabeticpatients have been observed in our previous studies. This long-term study was undertaken to assess the efficacy, safety and acceptability of camel milk as an adjunct to insulin therapy in type 1 diabetics. SUBJECTS/ METHODS: In this 2-year randomized clinical, parallel design study, 24 type 1 diabetics were enrolled and divided into two groups. Group I (n=12) received usual care, that is, diet, exercise and insulin and Group II (n=12) received 500 ml camel milk in addition to the usual care. Insulin requirement was titrated weekly by blood glucose estimation. Results were analyzed by using the regression technique. RESULTS: In camel milk group, there was decrease in mean blood glucose (118.58±19-93.16±17.06 mg/dl), hemoglobin A1c levels (7.81±1.39-5.44±0.81%) and insulin doses (32.50±9.99-17.50±12.09 U/day, P<0.05). Out of 12 subjects receiving camel milk, insulin requirement in 3 subjects reduced to zero. There was nonsignificant change in plasma insulin and anti-insulin antibodies in both the groups. CONCLUSION: It may be stated that camel milk is safe and efficacious in improving long-term glycemic control, with a significant reduction in the doses of insulin in type 1 diabeticpatients.
Authors: Kristy DiGiacomo; Fernanda Zamuner; Yushu Sun; Frank R Dunshea; Jared K Raynes; Brian J Leury Journal: Animals (Basel) Date: 2022-06-30 Impact factor: 3.231
Authors: Abdulrasheed O Abdulrahman; Mohammad A Ismael; Khaled Al-Hosaini; Christelle Rame; Abdulrahman M Al-Senaidy; Joëlle Dupont; Mohammed Akli Ayoub Journal: Front Endocrinol (Lausanne) Date: 2016-01-27 Impact factor: 5.555