BACKGROUND: The clinical relevance of chromosomally integrated human herpesvirus-6 (CIHHV-6) after transplantation is not known. This study was aimed to determine the potential role of CIHHV-6 on the occurrence of other infections, allograft rejection, and outcomes after liver transplantation. METHODS: A real-time quantitative human herpesvirus-6 (HHV-6) polymerase chain reaction assay was performed on whole blood samples of 548 liver transplant recipients. Clinical characteristics and outcomes of the patients with CIHHV-6 (defined as HHV-6 levels >1 × 10(6) genomes/mL) were compared with those of patients with low-level or no HHV-6 DNAemia. RESULTS: Seven had CIHHV-6, 35 had low-level HHV-6 DNAemia, and 506 had no HHV-6 DNAemia before liver transplantation. Bacterial infection was significantly more common in the CIHHV-6 group compared with the group without HHV-6 (71.4% vs. 31.4%; P = 0.04). A higher rate of allograft rejection was observed in the CIHHV-6 group compared with the group with low-level HHV-6 DNAemia (71.4% vs. 37.1%; P = 0.12) and those without HHV-6 DNAemia (71.4% vs. 42.9%; P = 0.25), although these differences did not reach statistical significance. Other opportunistic infections and outcomes were not significantly different between the CIHHV-6 group and the non-CIHHV-6 groups. CONCLUSION: Patients with CIHHV-6 may be at increased risk of indirect HHV6 effects after transplantation. This clinically relevant observation warrants confirmation using a larger cohort of transplant recipients.
BACKGROUND: The clinical relevance of chromosomally integrated human herpesvirus-6 (CIHHV-6) after transplantation is not known. This study was aimed to determine the potential role of CIHHV-6 on the occurrence of other infections, allograft rejection, and outcomes after liver transplantation. METHODS: A real-time quantitative human herpesvirus-6 (HHV-6) polymerase chain reaction assay was performed on whole blood samples of 548 liver transplant recipients. Clinical characteristics and outcomes of the patients with CIHHV-6 (defined as HHV-6 levels >1 × 10(6) genomes/mL) were compared with those of patients with low-level or no HHV-6 DNAemia. RESULTS: Seven had CIHHV-6, 35 had low-level HHV-6 DNAemia, and 506 had no HHV-6 DNAemia before liver transplantation. Bacterial infection was significantly more common in the CIHHV-6 group compared with the group without HHV-6 (71.4% vs. 31.4%; P = 0.04). A higher rate of allograft rejection was observed in the CIHHV-6 group compared with the group with low-level HHV-6 DNAemia (71.4% vs. 37.1%; P = 0.12) and those without HHV-6 DNAemia (71.4% vs. 42.9%; P = 0.25), although these differences did not reach statistical significance. Other opportunistic infections and outcomes were not significantly different between the CIHHV-6 group and the non-CIHHV-6 groups. CONCLUSION:Patients with CIHHV-6 may be at increased risk of indirect HHV6 effects after transplantation. This clinically relevant observation warrants confirmation using a larger cohort of transplant recipients.
Authors: Lena E Winestone; Rajesh Punn; John S Tamaresis; Julia Buckingham; Benjamin A Pinsky; Jesse J Waggoner; Sandhya Kharbanda Journal: Pediatr Transplant Date: 2017-11-27
Authors: E Bozzola; A Krzysztofiak; M Bozzola; V Calcaterra; A Quondamcarlo; L Lancella; A Villani Journal: Infection Date: 2012-07-18 Impact factor: 3.553
Authors: Joshua A Hill; Amalia S Magaret; Ruth Hall-Sedlak; Anna Mikhaylova; Meei-Li Huang; Brenda M Sandmaier; John A Hansen; Keith R Jerome; Danielle M Zerr; Michael Boeckh Journal: Blood Date: 2017-06-08 Impact factor: 22.113
Authors: Philip E Pellett; Dharam V Ablashi; Peter F Ambros; Henri Agut; Mary T Caserta; Vincent Descamps; Louis Flamand; Agnès Gautheret-Dejean; Caroline B Hall; Rammurti T Kamble; Uwe Kuehl; Dirk Lassner; Irmeli Lautenschlager; Kristin S Loomis; Mario Luppi; Paolo Lusso; Peter G Medveczky; Jose G Montoya; Yasuko Mori; Masao Ogata; Joshua C Pritchett; Sylvie Rogez; Edward Seto; Katherine N Ward; Tetsushi Yoshikawa; Raymund R Razonable Journal: Rev Med Virol Date: 2011-11-04 Impact factor: 6.989