Literature DB >> 21628702

The truth about genetic variation in the serotonin transporter gene and response to stress and medication.

Peter McGuffin, Shaza Alsabban, Rudolf Uher.   

Abstract

The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.

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Year:  2011        PMID： 21628702     DOI： 10.1192/bjp.bp.110.085225

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  20 in total

1.  Gene-by-environment experiments: a new approach to finding the missing heritability.

Authors:  Marinus H van Ijzendoorn; Marian J Bakermans-Kranenburg; Jay Belsky; Steven Beach; Gene Brody; Kenneth A Dodge; Mark Greenberg; Michael Posner; Stephen Scott
Journal:  Nat Rev Genet       Date:  2011-11-18       Impact factor: 53.242

2.  Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.

Authors:  Martin Korsbak Madsen; Brenda Mc Mahon; Sofie Bech Andersen; Hartwig Roman Siebner; Gitte Moos Knudsen; Patrick MacDonald Fisher
Journal:  Soc Cogn Affect Neurosci       Date:  2015-08-04       Impact factor: 3.436

3.  Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms.

Authors:  Elizabeth D Dalton; Constance L Hammen; Jake M Najman; Patricia A Brennan
Journal:  J Fam Psychol       Date:  2014-10-27

4.  Extending Previous cG×I Findings on 5-HTTLPR's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation.

Authors:  Gabriel L Schlomer; H Harrington Cleveland; Mark E Feinberg; Pedro S A Wolf; Mark T Greenberg; Richard L Spoth; Cleve Redmond; Eric P Tricou; David J Vandenbergh
Journal:  Child Dev       Date:  2016-11-08

Review 5.  Future directions in vulnerability to depression among youth: integrating risk factors and processes across multiple levels of analysis.

Authors:  Benjamin L Hankin
Journal:  J Clin Child Adolesc Psychol       Date:  2012-08-17

6.  Youth genetic vulnerability to maternal depressive symptoms: 5-HTTLPR as moderator of intergenerational transmission effects in a multiwave prospective study.

Authors:  Caroline W Oppenheimer; Benjamin L Hankin; Jami F Young; Andrew Smolen
Journal:  Depress Anxiety       Date:  2013-01-24       Impact factor: 6.505

7.  5-HTTLPR X stress in adolescent depression: moderation by MAOA and gender.

Authors:  Heather A Priess-Groben; Janet Shibley Hyde
Journal:  J Abnorm Child Psychol       Date:  2013-02

8.  Response to citalopram is not associated with SLC6A4 genotype in African-Americans and Caucasians with major depression.

Authors:  Russell E Poland; Ira M Lesser; Yu-Jui Yvonne Wan; Lev Gertsik; Jie Yao; Leslie J Raffel; Keh-Ming Lin; Hector F Myers
Journal:  Life Sci       Date:  2013-04-03       Impact factor: 5.037

Review 9.  Genetics as a molecular window into recovery, its treatment, and stress responses after stroke.

Authors:  Vanessa Juth; E Alison Holman; Michelle K Chan; Steven C Cramer
Journal:  J Investig Med       Date:  2016-04-04       Impact factor: 2.895

10.  Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN-BIND 1 report.

Authors:  Timothy A Allen; Kate L Harkness; Raymond W Lam; Roumen Milev; Benicio N Frey; Daniel J Mueller; Rudolf Uher; Sidney H Kennedy; Lena C Quilty
Journal:  Personal Ment Health       Date:  2021-05-18
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