Literature DB >> 21628659

Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19.

Robin McKenzie1, Chad K Porter, Joyce A Cantrell, Barbara Denearing, Aisling O'Dowd, Shannon L Grahek, Stephanie A Sincock, Colleen Woods, Peter Sebeny, David A Sack, David R Tribble, A Louis Bourgeois, Stephen J Savarino.   

Abstract

Human challenges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CS17 and CS19. LSN03-016011/A (LT, CS17) elicited a dose-dependent effect, with the upper dose (6 × 10(9) organisms) causing diarrhea in 88% of recipients. WS0115A (LTSTp, CS19) also showed a dose response, with a 44% diarrhea rate at 9 × 10(9) organisms. Both strains elicited homologous antifimbrial and anti-LT antibody seroconversion. These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LT|CS17-ETEC challenge model for interventional trials.

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Year:  2011        PMID： 21628659      PMCID： PMC3105037          DOI： 10.1093/infdis/jir220

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  16 in total

1.  Phenotypic profiles of enterotoxigenic Escherichia coli associated with early childhood diarrhea in rural Egypt.

Authors:  Hind I Shaheen; Sami B Khalil; Malla R Rao; Remon Abu Elyazeed; Thomas F Wierzba; Leonard F Peruski; Shannon Putnam; Armando Navarro; Badria Z Morsy; Alejandro Cravioto; John D Clemens; Ann-Mari Svennerholm; Stephen J Savarino
Journal:  J Clin Microbiol       Date:  2004-12       Impact factor: 5.948

2.  Prospective cohort study of enterotoxigenic Escherichia coli infections in Argentinean children.

Authors:  G I Viboud; M J Jouve; N Binsztein; M Vergara; M Rivas; M Quiroga; A M Svennerholm
Journal:  J Clin Microbiol       Date:  1999-09       Impact factor: 5.948

3.  Immune response, ciprofloxacin activity, and gender differences after human experimental challenge by two strains of enterotoxigenic Escherichia coli.

Authors:  T S Coster; M K Wolf; E R Hall; F J Cassels; D N Taylor; C T Liu; F C Trespalacios; A DeLorimier; D R Angleberger; C E McQueen
Journal:  Infect Immun       Date:  2006-10-30       Impact factor: 3.441

4.  Immunity to enterotoxigenic Escherichia coli.

Authors:  M M Levine; D R Nalin; D L Hoover; E J Bergquist; R B Hornick; C R Young
Journal:  Infect Immun       Date:  1979-03       Impact factor: 3.441

5.  Hemagglutination of human group A erythrocytes by enterotoxigenic Escherichia coli isolated from adults with diarrhea: correlation with colonization factor.

Authors:  D G Evans; D J Evans; W Tjoa
Journal:  Infect Immun       Date:  1977-11       Impact factor: 3.441

6.  Surveys of human enterotoxigenic Escherichia coli from three different geographical areas for possible colonization factors.

Authors:  M M McConnell; M L Hibberd; M E Penny; S M Scotland; T Cheasty; B Rowe
Journal:  Epidemiol Infect       Date:  1991-06       Impact factor: 2.451

7.  Transcutaneous immunization with the heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC): protective efficacy in a double-blind, placebo-controlled challenge study.

Authors:  Robin McKenzie; A Louis Bourgeois; Sarah A Frech; David C Flyer; Arlene Bloom; Kazem Kazempour; Gregory M Glenn
Journal:  Vaccine       Date:  2007-01-23       Impact factor: 3.641

8.  Comparative analyses of phenotypic and genotypic methods for detection of enterotoxigenic Escherichia coli toxins and colonization factors.

Authors:  A Sjöling; G Wiklund; S J Savarino; D I Cohen; A-M Svennerholm
Journal:  J Clin Microbiol       Date:  2007-08-08       Impact factor: 5.948

9.  Intestinal antibody response after oral immunization with a prototype cholera B subunit-colonization factor antigen enterotoxigenic Escherichia coli vaccine.

Authors:  C Ahrén; C Wennerås; J Holmgren; A M Svennerholm
Journal:  Vaccine       Date:  1993       Impact factor: 3.641

10.  Serologic differentiation between antitoxin responses to infection with Vibrio cholerae and enterotoxin-producing Escherichia coli.

Authors:  A M Svennerholm; J Holmgren; R Black; M Levine; M Merson
Journal:  J Infect Dis       Date:  1983-03       Impact factor: 5.226
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  9 in total

1.  Establishment and Validation of Pathogenic CS17+ and CS19+ Enterotoxigenic Escherichia coli Challenge Models in the New World Primate Aotus nancymaae.

Authors:  Eric R Hall; Aisling O'Dowd; Julianne E Rollenhagen; Nereyda Espinoza; Gladys Nunez; Stephen J Savarino
Journal:  Infect Immun       Date:  2021-02-16       Impact factor: 3.441

Review 2.  Controlled Human Infection Models To Accelerate Vaccine Development.

Authors:  Robert K M Choy; A Louis Bourgeois; Christian F Ockenhouse; Richard I Walker; Rebecca L Sheets; Jorge Flores
Journal:  Clin Microbiol Rev       Date:  2022-07-06       Impact factor: 50.129

Review 3.  Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access.

Authors:  Ibrahim Khalil; Richard Walker; Chad K Porter; Farzana Muhib; Roma Chilengi; Alejandro Cravioto; Richard Guerrant; Ann-Mari Svennerholm; Firdausi Qadri; Shahida Baqar; Margaret Kosek; Gagandeep Kang; Claudio Lanata; George Armah; Thomas Wierzba; Mateusz Hasso-Agopsowicz; Birgitte Giersing; A Louis Bourgeois
Journal:  Vaccine       Date:  2021-05-06       Impact factor: 3.641

4.  Diarrhea outbreak during U.S. military training in El Salvador.

Authors:  Matthew R Kasper; Andres G Lescano; Carmen Lucas; Duncan Gilles; Brian J Biese; Gary Stolovitz; Erik J Reaves
Journal:  PLoS One       Date:  2012-07-18       Impact factor: 3.240

5.  Toxins and virulence factors of enterotoxigenic Escherichia coli associated with strains isolated from indigenous children and international visitors to a rural community in Guatemala.

Authors:  O R Torres; W González; O Lemus; R A Pratdesaba; J A Matute; G Wiklund; D A Sack; A L Bourgeois; A-M Svennerholm
Journal:  Epidemiol Infect       Date:  2014-09-19       Impact factor: 2.451

6.  Genome and Functional Characterization of Colonization Factor Antigen I- and CS6-Encoding Heat-Stable Enterotoxin-Only Enterotoxigenic Escherichia coli Reveals Lineage and Geographic Variation.

Authors:  Tracy H Hazen; Sushma Nagaraj; Sunil Sen; Jasnehta Permala-Booth; Felipe Del Canto; Roberto Vidal; Eileen M Barry; Jacob P Bitoun; Wilbur H Chen; Sharon M Tennant; David A Rasko
Journal:  mSystems       Date:  2019-01-15       Impact factor: 6.496

Review 7.  A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies.

Authors:  Myron M Levine; Eileen M Barry; Wilbur H Chen
Journal:  Hum Vaccin Immunother       Date:  2019-03-20       Impact factor: 3.452

8.  An Evidenced-Based Scale of Disease Severity following Human Challenge with Enteroxigenic Escherichia coli.

Authors:  Chad K Porter; Mark S Riddle; Ashley N Alcala; David A Sack; Clayton Harro; Subhra Chakraborty; Ramiro L Gutierrez; Stephen J Savarino; Michael Darsley; Robin McKenzie; Barbara DeNearing; Hans Steinsland; David R Tribble; A Louis Bourgeois
Journal:  PLoS One       Date:  2016-03-03       Impact factor: 3.240

9.  Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS).

Authors:  Roberto M Vidal; Khitam Muhsen; Sharon M Tennant; Ann-Mari Svennerholm; Samba O Sow; Dipika Sur; Anita K M Zaidi; Abu S G Faruque; Debasish Saha; Richard Adegbola; M Jahangir Hossain; Pedro L Alonso; Robert F Breiman; Quique Bassat; Boubou Tamboura; Doh Sanogo; Uma Onwuchekwa; Byomkesh Manna; Thandavarayan Ramamurthy; Suman Kanungo; Shahnawaz Ahmed; Shahida Qureshi; Farheen Quadri; Anowar Hossain; Sumon K Das; Martin Antonio; Inacio Mandomando; Tacilta Nhampossa; Sozinho Acácio; Richard Omore; John B Ochieng; Joseph O Oundo; Eric D Mintz; Ciara E O'Reilly; Lynette Y Berkeley; Sofie Livio; Sandra Panchalingam; Dilruba Nasrin; Tamer H Farag; Yukun Wu; Halvor Sommerfelt; Roy M Robins-Browne; Felipe Del Canto; Tracy H Hazen; David A Rasko; Karen L Kotloff; James P Nataro; Myron M Levine
Journal:  PLoS Negl Trop Dis       Date:  2019-01-04
  9 in total

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