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Literature DB >> 2162804

DXS26 (HU16) is located in Xq21.1.

E M Sankila¹, G A Bruns, M Schwartz, E Nikoskelainen, E Niebuhr, S V Hodgson, A F Wright, A de la Chapelle.

Abstract

We have localized a single-copy DNA probe, HU16 (locus DXS26), to Xq21.1. The probe was isolated from a human-mouse hybrid X;13 library and mapped with human-mouse hybrids containing different portions of the human X chromosome and DNA from male patients with different X-chromosomal deletions. The following order of loci is proposed: Xcen-(DXS72,DXS169)-(DXS232,DSX26)-DXS1 21-DXS233-DXS165-TCD-DXS95-DXYS1-Xqter. HU16 will be useful in the study of the putative genes that reside in Xq21 and whose defects lead to deafness and mental retardation.

Entities: Disease Species

Mesh：

Substances：

Year: 1990 PMID： 2162804 DOI： 10.1007/BF00276335

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

28 in total

1. Complex glycerol kinase deficiency syndrome explained as X-chromosomal deletion.

Authors: B Wieringa; T Hustinx; J Scheres; W Renier; B ter Haar
Journal: Clin Genet Date: 1985-05 Impact factor: 4.438

Review 2. Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms.

Authors: K K Kidd; A M Bowcock; J Schmidtke; R K Track; F Ricciuti; G Hutchings; A Bale; P Pearson; H F Willard; J Gelernter
Journal: Cytogenet Cell Genet Date: 1989

3. Linkage studies with the gene for an X-linked syndrome of mental retardation, microcephaly and spastic diplegia (MRX2)

Authors: G R Sutherland; A K Gedeon; E A Haan; P Woodroffe; J C Mulley
Journal: Am J Med Genet Date: 1988 May-Jun

4. A non-syndromal form of X-linked mental retardation (XLMR) is linked to DXS14.

Authors: G K Suthers; G Turner; J C Mulley
Journal: Am J Med Genet Date: 1988 May-Jun

5. Isolation of DNA fragments from chromosome 13.

Authors: T P Dryja; G A Bruns; S H Orkin; D M Albert; P S Gerald
Journal: Retina Date: 1983 Impact factor: 4.256

6. Choroideremia. A clinical and genetic study of 84 Finnish patients and 126 female carriers.

Authors: J Kärnä
Journal: Acta Ophthalmol Suppl Date: 1986

7. Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids.

Authors: P Wieacker; K E Davies; H J Cooke; P L Pearson; R Williamson; S Bhattacharya; J Zimmer; H H Ropers
Journal: Am J Hum Genet Date: 1984-03 Impact factor: 11.025

Review 8. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors: D Botstein; R L White; M Skolnick; R W Davis
Journal: Am J Hum Genet Date: 1980-05 Impact factor: 11.025

9. Regional localization of polymorphic DNA loci on the proximal long arm of the X chromosome using deletions associated with choroideremia.

Authors: M Schwartz; H M Yang; E Niebuhr; T Rosenberg; D C Page
Journal: Hum Genet Date: 1988-02 Impact factor: 4.132

10. Chromosomal jumping from the DXS165 locus allows molecular characterization of four microdeletions and a de novo chromosome X/13 translocation associated with choroideremia.

Authors: F P Cremers; D J van de Pol; B Wieringa; F S Collins; E M Sankila; V M Siu; W F Flintoff; F Brunsmann; L A Blonden; H H Ropers
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

5 in total

DXS26 (HU16) is located in Xq21.1.

1. Complex glycerol kinase deficiency syndrome explained as X-chromosomal deletion.

Review 2. Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms.

3. Linkage studies with the gene for an X-linked syndrome of mental retardation, microcephaly and spastic diplegia (MRX2)

4. A non-syndromal form of X-linked mental retardation (XLMR) is linked to DXS14.

5. Isolation of DNA fragments from chromosome 13.

6. Choroideremia. A clinical and genetic study of 84 Finnish patients and 126 female carriers.

7. Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids.

Review 8. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

9. Regional localization of polymorphic DNA loci on the proximal long arm of the X chromosome using deletions associated with choroideremia.

10. Chromosomal jumping from the DXS165 locus allows molecular characterization of four microdeletions and a de novo chromosome X/13 translocation associated with choroideremia.

1. Physical fine mapping of genes underlying X-linked deafness and non fra (X)-X-linked mental retardation at Xq21.

2. Microdeletions in patients with gusher-associated, X-linked mixed deafness (DFN3).

3. Deletions in patients with classical choroideremia vary in size from 45 kb to several megabases.

4. Deletion mapping of X-linked mixed deafness (DFN3) identifies a 265-525-kb region centromeric of DXS26.

5. Choroideremia: linkage analysis with physically mapped close DNA-markers.