OBJECTIVE: To evaluate whether neuroendocrine forms of secondary amenorrhea (hypothalamic nervosa (HA) and anorexia nervosa (AN)) affect serum anti-Müllerian hormone (AMH), inhibin B, and total inhibin levels. METHODS: Amenorrheic women (n = 82) (aged between 16 and 35 years old) according to diagnosed with neuroendocrine forms of amenorrhea: HA (n = 64), AN (n = 18), and healthy women (n = 41) (control group) were enrolled. Serum AMH, inhibin B, and total inhibin levels were measured by specific ELISA. RESULTS: No statistically significant difference of AMH serum levels between women with HA, AN, and control group was observed. Serum inhibin B and total inhibin levels in women with HA (p < 0.0001), AN (p < 0.05) resulted significantly lower than in control healthy women. CONCLUSION: The present data showed that neuroendocrine forms of amenorrhea are associated with an impaired inhibin secretion while not AMH. These data indirectly support that AMH is an excellent marker of ovarian reserve and its secretion is not influenced by the hypothalamic-ovarian axis activity.
OBJECTIVE: To evaluate whether neuroendocrine forms of secondary amenorrhea (hypothalamic nervosa (HA) and anorexia nervosa (AN)) affect serum anti-Müllerian hormone (AMH), inhibin B, and total inhibin levels. METHODS: Amenorrheic women (n = 82) (aged between 16 and 35 years old) according to diagnosed with neuroendocrine forms of amenorrhea: HA (n = 64), AN (n = 18), and healthy women (n = 41) (control group) were enrolled. Serum AMH, inhibin B, and total inhibin levels were measured by specific ELISA. RESULTS: No statistically significant difference of AMH serum levels between women with HA, AN, and control group was observed. Serum inhibin B and total inhibin levels in women with HA (p < 0.0001), AN (p < 0.05) resulted significantly lower than in control healthy women. CONCLUSION: The present data showed that neuroendocrine forms of amenorrhea are associated with an impaired inhibin secretion while not AMH. These data indirectly support that AMH is an excellent marker of ovarian reserve and its secretion is not influenced by the hypothalamic-ovarian axis activity.
Authors: M Sönmezer; B Özmen; C S Atabekoglu; E G Papuccu; S Ozkavukcu; B Berker; R Pabuccu Journal: J Assist Reprod Genet Date: 2012-05-01 Impact factor: 3.412
Authors: Klara Beitl; Didier Dewailly; Rudolf Seemann; Marlene Hager; Jakob Bünker; Daniel Mayrhofer; Iris Holzer; Johannes Ott Journal: Front Endocrinol (Lausanne) Date: 2022-06-02 Impact factor: 6.055
Authors: Laura Mensi; Raffaella Borroni; Marco Reschini; Elena Cassinerio; Walter Vegetti; Marina Baldini; Maria Domenica Cappellini; Edgardo Somigliana Journal: Eur J Obstet Gynecol Reprod Biol X Date: 2019-05-13