Literature DB >> 21627047

Epigenetic deregulation in rheumatoid arthritis.

Emmanuel Karouzakis1, Renate E Gay, Steffen Gay, Michel Neidhart.   

Abstract

In this chapter, we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis. In particular, we describe that deregulation ofDNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis. In addition, we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity. Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter. In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease.

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Year:  2011        PMID： 21627047     DOI： 10.1007/978-1-4419-8216-2_10

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  10 in total

Review 1.  Cytokine gene considerations in giant cell arteritis: IL10 promoter polymorphisms and a review of the literature.

Authors:  Lorena Alvarez-Rodriguez; Marcos Lopez-Hoyos; Eugenio Carrasco-Marín; Gaurav Tripathi; Pedro Muñoz Cacho; Cristina Mata; Jaime Calvo-Alen; Maite Garcia-Unzueta; Elena Aurrecoechea; Victor Manuel Martinez-Taboada
Journal:  Clin Rev Allergy Immunol       Date:  2014-08       Impact factor: 8.667

Review 2.  Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.

Authors:  Nunzio Bottini; Gary S Firestein
Journal:  Nat Rev Rheumatol       Date:  2012-11-13       Impact factor: 20.543

Review 3.  Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes.

Authors:  Gyrid Nygaard; Gary S Firestein
Journal:  Nat Rev Rheumatol       Date:  2020-05-11       Impact factor: 20.543

4.  Batch correction of microarray data substantially improves the identification of genes differentially expressed in rheumatoid arthritis and osteoarthritis.

Authors:  Peter Kupfer; Reinhard Guthke; Dirk Pohlers; Rene Huber; Dirk Koczan; Raimund W Kinne
Journal:  BMC Med Genomics       Date:  2012-06-08       Impact factor: 3.063

5.  The BRIC-GARN Meeting 2011: of mice and men.

Authors:  David S Pisetsky
Journal:  Arthritis Res Ther       Date:  2012-02-24       Impact factor: 5.156

6.  Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects.

Authors:  Paolo Tieri; XiaoYuan Zhou; Lisha Zhu; Christine Nardini
Journal:  Front Cell Dev Biol       Date:  2014-11-04

7.  METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway.

Authors:  Jinghua Wang; Shushan Yan; Hongying Lu; Shufeng Wang; Donghua Xu
Journal:  Mediators Inflamm       Date:  2019-10-24       Impact factor: 4.711

8.  Aging is associated with increased regulatory T-cell function.

Authors:  Sanjay K Garg; Colin Delaney; Tomomi Toubai; Amiya Ghosh; Pavan Reddy; Ruma Banerjee; Raymond Yung
Journal:  Aging Cell       Date:  2014-02-25       Impact factor: 9.304

9.  Effects of Wutou Decoction on DNA Methylation and Histone Modifications in Rats with Collagen-Induced Arthritis.

Authors:  Ya-Fei Liu; Cai-Yu-Zhu Wen; Zhe Chen; Yu Wang; Ying Huang; Yong-Hong Hu; Sheng-Hao Tu
Journal:  Evid Based Complement Alternat Med       Date:  2016-03-06       Impact factor: 2.629

10.  Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis.

Authors:  Emmanuel Karouzakis; Karim Raza; Christoph Kolling; Christopher D Buckley; Steffen Gay; Andrew Filer; Caroline Ospelt
Journal:  Sci Rep       Date:  2018-05-09       Impact factor: 4.379
  10 in total

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