| Literature DB >> 21625948 |
Mohan G Kalaskar1, Sanjay J Surana.
Abstract
Successive extracts of Ficus microcarpa L. fil. bark (FMB) were tested for antioxidant and hepatoprotective activity against carbon tetrachloride- and paracetamol-induced hepatotoxicities in rats. The ethyl acetate extract of FMB exhibited significant antioxidant and hepatoprotective activity by reducing carbon tetrachloride- and paracetamol-induced changes in biochemical parameters as evidenced by enzymatic and histological examination. Pretreatment with ethyl acetate extract of FMB significantly shortened the duration of pentobarbitone-induced necrosis in mice, indicating its hepatoprotective potential. Phytochemical studies confirmed the presence of the phenolic compound, catechin, in FMB, which may interfere with free-radical formation and may account for its significant hepatoprotective effects. The present study thus provides a scientific rationale for the traditional use of this plant in the management of liver disorders.Entities:
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Year: 2011 PMID： 21625948 DOI： 10.1007/s11418-011-0532-z
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343