Literature DB >> 2162560

Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1.

R J Kaner1, A Baird, A Mansukhani, C Basilico, B D Summers, R Z Florkiewicz, D P Hajjar.   

Abstract

Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen responsible for considerable morbidity in the general population. The results presented herein establish the basic fibroblast growth factor (FGF) receptor as a means of entry of HSV-1 into vertebrate cells. Inhibitors of basic FGF binding to its receptor and competitive polypeptide antagonists of basic FGF prevented HSV-1 uptake. Chinese hamster ovary (CHO) cells that do not express FGF receptors are resistant to HSV-1 entry; however, HSV-1 uptake is dramatically increased in CHO cells transfected with a complementary DNA encoding a basic FGF receptor. The distribution of this integral membrane protein in vivo may explain the tissue and cell tropism of HSV-1.

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Year:  1990        PMID： 2162560     DOI： 10.1126/science.2162560

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry.

Authors:  J C Whitbeck; C Peng; H Lou; R Xu; S H Willis; M Ponce de Leon; T Peng; A V Nicola; R I Montgomery; M S Warner; A M Soulika; L A Spruce; W T Moore; J D Lambris; P G Spear; G H Cohen; R J Eisenberg
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Infection of polarized MDCK cells with herpes simplex virus 1: two asymmetrically distributed cell receptors interact with different viral proteins.

Authors:  A E Sears; B S McGwire; B Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

3.  Involvement of glycoprotein C (gC) in adsorption of herpes simplex virus type 1 (HSV-1) to the cell.

Authors:  B Svennerholm; S Jeansson; A Vahlne; E Lycke
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

4.  Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity.

Authors:  B C Herold; D WuDunn; N Soltys; P G Spear
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

5.  Characterization of fusion from without induced by herpes simplex virus.

Authors:  I Walev; K C Wollert; K Weise; D Falke
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

6.  Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.

Authors:  C Krummenacher; A V Nicola; J C Whitbeck; H Lou; W Hou; J D Lambris; R J Geraghty; P G Spear; G H Cohen; R J Eisenberg
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

7.  Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor.

Authors:  M C Kiefer; J C Stephans; K Crawford; K Okino; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 8.  Warner-Lambert/Parke-Davis Award Lecture. Viral pathogenesis of atherosclerosis. Impact of molecular mimicry and viral genes.

Authors:  D P Hajjar
Journal:  Am J Pathol       Date:  1991-12       Impact factor: 4.307

9.  Discrimination of herpes simplex virus types 1 and 2 cerebral infections in a rat model.

Authors:  T Bergström; B Svennerholm; N Conradi; P Horal; A Vahlne
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

10.  Identification of cell surface molecules that interact with pseudorabies virus.

Authors:  A Karger; T C Mettenleiter
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103
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