BACKGROUND: 2009 influenza A has spread globally. Respiratory complications and renal failure have been the leading causes for hospitalization and critical illness. We describe the risk factors and complications of acute kidney injury (AKI) in patients with influenza A. METHODS: Observational study of adult patients tested for influenza A. Outcome measures include AKI [AKI Network (AKIN) criteria] and mortality. RESULTS: From August through December 2009, 17% (89/515) of hospitalized subjects were tested positive for influenza A. The incidence of AKI (AKIN(I-III)) was 42% (37/89) in subjects with influenza A; the majority (65%, 24/37) of whom were critically ill. Risk factors for AKI included obesity, chronic kidney disease (CKD), and elevated creatine kinase. Positive influenza A status was associated with lower AKI (AKIN(I-III)) risk compared to seronegative subjects (OR 0.5, CI 0.3-0.9). Mortality in patients with influenza A and AKI requiring dialysis was 50%. CONCLUSIONS: Obesity, CKD, and elevated creatine kinase are associated with AKI in patients with influenza A. Influenza A is not independently associated with higher incidence of AKI in hospitalized patients. AKI is an independent risk factor for mortality in patients with influenza A.
BACKGROUND: 2009 influenza A has spread globally. Respiratory complications and renal failure have been the leading causes for hospitalization and critical illness. We describe the risk factors and complications of acute kidney injury (AKI) in patients with influenza A. METHODS: Observational study of adult patients tested for influenza A. Outcome measures include AKI [AKI Network (AKIN) criteria] and mortality. RESULTS: From August through December 2009, 17% (89/515) of hospitalized subjects were tested positive for influenza A. The incidence of AKI (AKIN(I-III)) was 42% (37/89) in subjects with influenza A; the majority (65%, 24/37) of whom were critically ill. Risk factors for AKI included obesity, chronic kidney disease (CKD), and elevated creatine kinase. Positive influenza A status was associated with lower AKI (AKIN(I-III)) risk compared to seronegative subjects (OR 0.5, CI 0.3-0.9). Mortality in patients with influenza A and AKI requiring dialysis was 50%. CONCLUSIONS:Obesity, CKD, and elevated creatine kinase are associated with AKI in patients with influenza A. Influenza A is not independently associated with higher incidence of AKI in hospitalized patients. AKI is an independent risk factor for mortality in patients with influenza A.
Authors: Bhavna Bhasin; Vineet Veitla; Aprill Z Dawson; Zhuping Garacci; Daniel Sturgill; Mukoso N Ozieh; Kevin R Regner Journal: Kidney360 Date: 2021-02-26
Authors: Shruti Gupta; Steven G Coca; Lili Chan; Michal L Melamed; Samantha K Brenner; Salim S Hayek; Anne Sutherland; Sonika Puri; Anand Srivastava; Amanda Leonberg-Yoo; Alexandre M Shehata; Jennifer E Flythe; Arash Rashidi; Edward J Schenck; Nitender Goyal; S Susan Hedayati; Rajany Dy; Anip Bansal; Ambarish Athavale; H Bryant Nguyen; Anitha Vijayan; David M Charytan; Carl E Schulze; Min J Joo; Allon N Friedman; Jingjing Zhang; Marie Anne Sosa; Eric Judd; Juan Carlos Q Velez; Mary Mallappallil; Roberta E Redfern; Amar D Bansal; Javier A Neyra; Kathleen D Liu; Amanda D Renaghan; Marta Christov; Miklos Z Molnar; Shreyak Sharma; Omer Kamal; Jeffery Owusu Boateng; Samuel A P Short; Andrew J Admon; Meghan E Sise; Wei Wang; Chirag R Parikh; David E Leaf Journal: J Am Soc Nephrol Date: 2020-10-16 Impact factor: 10.121
Authors: Subhashini A Sellers; Robert S Hagan; Frederick G Hayden; William A Fischer Journal: Influenza Other Respir Viruses Date: 2017-09 Impact factor: 4.380
Authors: Lili Chan; Kumardeep Chaudhary; Aparna Saha; Kinsuk Chauhan; Akhil Vaid; Shan Zhao; Ishan Paranjpe; Sulaiman Somani; Felix Richter; Riccardo Miotto; Anuradha Lala; Arash Kia; Prem Timsina; Li Li; Robert Freeman; Rong Chen; Jagat Narula; Allan C Just; Carol Horowitz; Zahi Fayad; Carlos Cordon-Cardo; Eric Schadt; Matthew A Levin; David L Reich; Valentin Fuster; Barbara Murphy; John C He; Alexander W Charney; Erwin P Böttinger; Benjamin S Glicksberg; Steven G Coca; Girish N Nadkarni Journal: J Am Soc Nephrol Date: 2020-09-03 Impact factor: 10.121
Authors: Ian A Strohbehn; Sophia Zhao; Harish Seethapathy; Meghan Lee; Nifasha Rusibamayila; Andrew S Allegretti; Xavier Vela Parada; Meghan E Sise Journal: Kidney Int Rep Date: 2021-07-15