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Literature DB >> 21624798

Notch and basal cells take center stage during airway epithelial regeneration.

Jeffrey A Whitsett¹, Vladimir V Kalinichenko.

Abstract

Airway epithelium is maintained by basal cells, but the mechanisms responsible for repair are poorly characterized. In this issue of Cell Stem Cell, Rock et al. (2011) show that Notch signals regulate differentiation, but not self-renewal of basal cells after injury, and that this role appears conserved in mouse and human lung.

Entities: Species

Year: 2011 PMID： 21624798 DOI： 10.1016/j.stem.2011.05.008

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

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Cited

13 in total

Review 1. In Vitro Models to Study Human Lung Development, Disease and Homeostasis.

Authors: Alyssa J Miller; Jason R Spence
Journal: Physiology (Bethesda) Date: 2017-05

2. Mesenchymal deficiency of Notch1 attenuates bleomycin-induced pulmonary fibrosis.

Authors: Biao Hu; Zhe Wu; David Bai; Tianju Liu; Matthew R Ullenbruch; Sem H Phan
Journal: Am J Pathol Date: 2015-09-08 Impact factor: 4.307

3. Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways.

Authors: Vladimir Ustiyan; Susan E Wert; Machiko Ikegami; I-Ching Wang; Tanya V Kalin; Jeffrey A Whitsett; Vladimir V Kalinichenko
Journal: Dev Biol Date: 2012-08-02 Impact factor: 3.582

4. Myb permits multilineage airway epithelial cell differentiation.

Authors: Jie-Hong Pan; Tracy L Adair-Kirk; Anand C Patel; Tao Huang; Nicholas S Yozamp; Jian Xu; E Premkumar Reddy; Derek E Byers; Richard A Pierce; Michael J Holtzman; Steven L Brody
Journal: Stem Cells Date: 2014-12 Impact factor: 6.277

Review 5. The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.

Authors: Xilei Xu-Chen; Jered Weinstock; Deepa Rastogi; Anastassios Koumbourlis; Gustavo Nino
Journal: Paediatr Respir Rev Date: 2021-04-22 Impact factor: 2.726

Notch and basal cells take center stage during airway epithelial regeneration.

Review 1. In Vitro Models to Study Human Lung Development, Disease and Homeostasis.

2. Mesenchymal deficiency of Notch1 attenuates bleomycin-induced pulmonary fibrosis.

3. Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways.

4. Myb permits multilineage airway epithelial cell differentiation.

Review 5. The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.

Review 6. The pathogenesis of COPD and IPF: distinct horns of the same devil?

7. Notch signaling is active in normal mouse middle ear epithelial cells.

8. Acute lung injury: how macrophages orchestrate resolution of inflammation and tissue repair.

9. The Role of the Notch Signal Pathway in Mucosal Cell Metaplasia in Mouse Acute Otitis Media.

10. Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis.