Literature DB >> 21624722

Hypertrophic scar.

Vincent Gabriel1.   

Abstract

Hypertrophic scars are common complications of burn injury and other soft tissue injuries. Excessive extracellular matrix combined with inadequate remodeling of scar tissue results in an aesthetically and functionally unsatisfactory, painful, pruritic scar that can impair function. Treatment options are available to rehabilitation practitioners, but none are entirely satisfactory. An interdisciplinary clinical program is necessary for best outcomes. Challenges to be met by the rehabilitation community include research into the quantification of burn scar measurement, the effects of mechanical forces on wound healing and scar management, and the best combination of surgical, pharmacologic, and therapy interventions to maximize outcome from reconstructive procedures.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 21624722     DOI: 10.1016/j.pmr.2011.02.002

Source DB:  PubMed          Journal:  Phys Med Rehabil Clin N Am        ISSN: 1047-9651            Impact factor:   1.784


  11 in total

1.  Clodronate liposomes reduce excessive scar formation in a mouse model of burn injury by reducing collagen deposition and TGF-β1 expression.

Authors:  Shao-Wei Lu; Xing-Mei Zhang; Hong-Min Luo; Yu-Cai Fu; Ming-Yan Xu; Shi-Jie Tang
Journal:  Mol Biol Rep       Date:  2014-01-19       Impact factor: 2.316

2.  Uighur medicine abnormal savda munzip (ASMq) suppresses expression of collagen and TGF-β1 with concomitant induce Smad7 in human hypertrophic scar fibroblasts.

Authors:  Nan Li; Menglong Kong; Tao Ma; Weicheng Gao; Shaolin Ma
Journal:  Int J Clin Exp Med       Date:  2015-06-15

3.  Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies.

Authors:  Zhenping Chen; Jianhua Gu; Amina El Ayadi; Andres F Oberhauser; Jia Zhou; Linda E Sousse; Celeste C Finnerty; David N Herndon; Paul J Boor
Journal:  Toxicol Appl Pharmacol       Date:  2018-09-22       Impact factor: 4.219

4.  Investigating the potential of Shikonin as a novel hypertrophic scar treatment.

Authors:  Chen Fan; Yan Xie; Ying Dong; Yonghua Su; Zee Upton
Journal:  J Biomed Sci       Date:  2015-08-16       Impact factor: 8.410

5.  Mesenchymal stem cell-mediated suppression of hypertrophic scarring is p53 dependent in a rabbit ear model.

Authors:  Yi-Lun Liu; Wei-Hua Liu; Jin Sun; Tuan-Jie Hou; Yue-Ming Liu; Hai-Rong Liu; Yong-Hui Luo; Ning-Ning Zhao; Ying Tang; Feng-Mei Deng
Journal:  Stem Cell Res Ther       Date:  2014-12-15       Impact factor: 6.832

6.  MicroRNA expression signature and the therapeutic effect of the microRNA‑21 antagomir in hypertrophic scarring.

Authors:  Liang Guo; Kai Xu; Hongbo Yan; Haifeng Feng; Tao Wang; Linlin Chai; Guozheng Xu
Journal:  Mol Med Rep       Date:  2017-01-05       Impact factor: 2.952

7.  Effect of pressure therapy for treatment of hypertrophic scar.

Authors:  Hao Zhang; Hao-Yan Wang; Da-Li Wang; Xiao-Dong Zhang
Journal:  Medicine (Baltimore)       Date:  2019-06       Impact factor: 1.817

8.  Bone marrow concentrate-induced mesenchymal stem cell conditioned medium facilitates wound healing and prevents hypertrophic scar formation in a rabbit ear model.

Authors:  Ching-Hsuan Hu; Yi-Wen Tseng; Chih-Yung Chiou; Kuan-Chun Lan; Chih-Hung Chou; Chun-San Tai; Hsien-Da Huang; Chiung-Wen Hu; Ko-Hsun Liao; Shiow-Shuh Chuang; Jui-Yung Yang; Oscar K Lee
Journal:  Stem Cell Res Ther       Date:  2019-08-28       Impact factor: 6.832

9.  Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression.

Authors:  Hu Xiao; Dechang Wang; Ran Huo; Yibing Wang; Yongqiang Feng; Qiang Li
Journal:  Neural Regen Res       Date:  2013-06-15       Impact factor: 5.135

10.  iTRAQ-based proteomic profiling reveals different protein expression between normal skin and hypertrophic scar tissue.

Authors:  Jianglin Tan; Weifeng He; Gaoxing Luo; Jun Wu
Journal:  Burns Trauma       Date:  2015-08-27
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