Literature DB >> 21623357

FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.

Kyung-Jo Lee1, Chang-Sook Jeong, Young Jun An, Hyun-Jung Lee, Soon-Jung Park, Yeong-Jae Seok, Pil Kim, Jung-Hyun Lee, Kyu-Ho Lee, Sun-Shin Cha.   

Abstract

The interaction between fermentation-respiration switch (FrsA) protein and glucose-specific enzyme IIA(Glc) increases glucose fermentation under oxygen-limited conditions. We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues required for catalysis as well as the structural basis for the activation by d-IIA(Glc).

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Year:  2011        PMID： 21623357     DOI： 10.1038/nchembio.589

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  24 in total

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Authors:  B G Miller; A M Hassell; R Wolfenden; M V Milburn; S A Short
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Review 4.  Binding energy, specificity, and enzymic catalysis: the circe effect.

Authors:  W P Jencks
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1975

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Authors:  M P Stephenson; E A Dawes
Journal:  J Gen Microbiol       Date:  1971-12

Review 9.  Bacterial adenylyl cyclases.

Authors:  A Peterkofsky; A Reizer; J Reizer; N Gollop; P P Zhu; N Amin
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