| Literature DB >> 21621856 |
Takafumi Hosokawa1, Hideto Nakajima, Yoshimitsu Doi, Masakazu Sugino, Fumiharu Kimura, Toshiaki Hanafusa, Toshiyuki Takahashi.
Abstract
Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption.Entities:
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Year: 2011 PMID： 21621856 DOI： 10.1016/j.jneuroim.2011.04.009
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478