| Literature DB >> 21621414 |
Raju Suresh Kumar1, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran.
Abstract
Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.72 μmol/L.Entities:
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Year: 2011 PMID： 21621414 DOI： 10.1016/j.bmcl.2011.05.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823