Literature DB >> 21621326

Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway.

Mei-Chuan Tang1, Li-Chuan Chan, Yi-Chen Yeh, Cheng-Yu Chen, Teh-Ying Chou, Wei-Shu Wang, Yeu Su.   

Abstract

Thymosin β(4) (Tβ(4)) overexpression increases cell migration and tumor metastasis. Hence, understanding the mechanism of cancer cell migration induced by Tβ(4) may provide means to inhibit their metastasis. We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells. In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ(4) simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability. These findings suggest that Tβ(4) increases migration of colon cancer cells via activating Rac1 by elevating IQGAP1/ILK complexes and IHC results illustrated a similar mechanism occurring in vivo.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 21621326     DOI： 10.1016/j.canlet.2011.05.001

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  13 in total

1.  Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex.

Authors:  Mirela Spillane; Andrea Ketschek; Chris J Donnelly; Almudena Pacheco; Jeffrey L Twiss; Gianluca Gallo
Journal:  J Neurosci       Date:  2012-12-05       Impact factor: 6.167

Review 2.  Biomarkers for predicting future metastasis of human gastrointestinal tumors.

Authors:  Lui Ng; Ronnie Tung Ping Poon; Roberta Pang
Journal:  Cell Mol Life Sci       Date:  2013-01-31       Impact factor: 9.261

3.  Identification of thymosins β4 and β 10 in paediatric craniopharyngioma cystic fluid.

Authors:  Claudia Desiderio; Claudia Martelli; Diana Valeria Rossetti; Concezio Di Rocco; Luca D'Angelo; Massimo Caldarelli; Gianpiero Tamburrini; Federica Iavarone; Massimo Castagnola; Irene Messana; Tiziana Cabras; Gavino Faa
Journal:  Childs Nerv Syst       Date:  2013-03-17       Impact factor: 1.475

4.  Thymosin β10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production.

Authors:  Young-Chae Kim; Byoung-Gie Kim; Je-Ho Lee
Journal:  PLoS One       Date:  2012-05-18       Impact factor: 3.240

5.  Thymosin β4 cytoplasmic/nuclear translocation as a new marker of cellular stress. A Caco2 case study.

Authors:  Pierpaolo Coni; Monica Piras; Anna Mateddu; Marco Piludu; Germano Orru; Alessandra Scano; Tiziana Cabras; Valentina Piras; Joanna Izabela Lachowicz; Mariusz Jaremko; Gavino Faa; Massimo Castagnola; Giuseppina Pichiri
Journal:  RSC Adv       Date:  2020-03-30       Impact factor: 4.036

6.  IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.

Authors:  Amr M Ghaleb; Agnieszka B Bialkowska; Ashley J Snider; Dmitri V Gnatenko; Yusuf A Hannun; Vincent W Yang; Valentina A Schmidt
Journal:  PLoS One       Date:  2015-06-05       Impact factor: 3.240

7.  Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4.

Authors:  Jae-Wook Lee; Yun-Kyoung Ryu; Young-Hoon Ji; Joo Hyun Kang; Eun-Yi Moon
Journal:  Oncotarget       Date:  2015

8.  Increased Expression of Thymosin β4 Is Independently Correlated with Hypoxia Inducible Factor-1α (HIF-1α) and Worse Clinical Outcome in Human Colorectal Cancer.

Authors:  Seung Yun Lee; Mee Ja Park; Hye Kyung Lee; Hyun Jin Son; Chang Nam Kim; Joo Heon Kim; Dong Wook Kang
Journal:  J Pathol Transl Med       Date:  2016-10-16

9.  β-thymosins and hemocyte homeostasis in a crustacean.

Authors:  Netnapa Saelee; Chadanat Noonin; Benjamas Nupan; Kingkamon Junkunlo; Amornrat Phongdara; Xionghui Lin; Kenneth Söderhäll; Irene Söderhäll
Journal:  PLoS One       Date:  2013-04-02       Impact factor: 3.240

10.  Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma.

Authors:  W Theunissen; D Fanni; S Nemolato; E Di Felice; T Cabras; C Gerosa; P Van Eyken; I Messana; M Castagnola; G Faa
Journal:  Eur J Histochem       Date:  2014-03-11       Impact factor: 3.188
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