BACKGROUND: Although Mexicans and Puerto Ricans are jointly classified as "Hispanic/Latino," there are significant differences in asthma prevalence, severity, and mortality between the 2 groups. We sought to examine the possibility that population-specific genetic risks contribute to this disparity. OBJECTIVES: More than 100 candidate genes have been associated with asthma and replicated in an independent population, and 7 genome-wide association studies in asthma have been performed. We compared the pattern of replication of these associations in Puerto Ricans and Mexicans. METHODS: We genotyped Mexican and Puerto Rican trios using an Affymetrix 6.0 GeneChip and used a family-based analysis to test for genetic associations in 124 genes previously associated with asthma. RESULTS: We identified 32 single nucleotide polymorphisms (SNPs) in 17 genes associated with asthma in at least 1 of the 2 populations. Twenty-two of these SNPs in 11 genes were significantly associated with asthma in the combined population and showed no significant heterogeneity of association, whereas 5 SNPs were associated in only 1 population and showed statistically significant heterogeneity. In a gene-based approach 2 additional genes were associated with asthma in the combined population, and 3 additional genes displayed ethnic-specific associations with heterogeneity. CONCLUSIONS: Our results show that only a minority of genetic association studies replicate in our population of Mexican and Puerto Rican asthmatic subjects. Among SNPs that were successfully replicated, most showed no significant heterogeneity across populations. However, we identified several population-specific genetic associations.
BACKGROUND: Although Mexicans and Puerto Ricans are jointly classified as "Hispanic/Latino," there are significant differences in asthma prevalence, severity, and mortality between the 2 groups. We sought to examine the possibility that population-specific genetic risks contribute to this disparity. OBJECTIVES: More than 100 candidate genes have been associated with asthma and replicated in an independent population, and 7 genome-wide association studies in asthma have been performed. We compared the pattern of replication of these associations in Puerto Ricans and Mexicans. METHODS: We genotyped Mexican and Puerto Rican trios using an Affymetrix 6.0 GeneChip and used a family-based analysis to test for genetic associations in 124 genes previously associated with asthma. RESULTS: We identified 32 single nucleotide polymorphisms (SNPs) in 17 genes associated with asthma in at least 1 of the 2 populations. Twenty-two of these SNPs in 11 genes were significantly associated with asthma in the combined population and showed no significant heterogeneity of association, whereas 5 SNPs were associated in only 1 population and showed statistically significant heterogeneity. In a gene-based approach 2 additional genes were associated with asthma in the combined population, and 3 additional genes displayed ethnic-specific associations with heterogeneity. CONCLUSIONS: Our results show that only a minority of genetic association studies replicate in our population of Mexican and Puerto Rican asthmatic subjects. Among SNPs that were successfully replicated, most showed no significant heterogeneity across populations. However, we identified several population-specific genetic associations.
Authors: Dianne Keen-Kim; Carol A Mathews; Victor I Reus; Thomas L Lowe; Luis Diego Herrera; Cathy L Budman; Varda Gross-Tsur; Ann E Pulver; Ruth D Bruun; Gerald Erenberg; Allan Naarden; Chiara Sabatti; Nelson B Freimer Journal: Hum Mol Genet Date: 2006-10-11 Impact factor: 6.150
Authors: Shweta Choudhry; Ngim Ung; Pedro C Avila; Elad Ziv; Sylvette Nazario; Jesus Casal; Alfonso Torres; Jennifer D Gorman; Keyan Salari; Jose R Rodriguez-Santana; Monica Toscano; Jody Senter Sylvia; MariaElena Alioto; Richard A Castro; Michael Salazar; Ivan Gomez; Joanne K Fagan; Jorge Salas; Suzanne Clark; Craig Lilly; Henry Matallana; Moises Selman; Rocio Chapela; Dean Sheppard; Scott T Weiss; Jean G Ford; Homer A Boushey; Jeffrey M Drazen; William Rodriguez-Cintron; Edwin K Silverman; Esteban González Burchard Journal: Am J Respir Crit Care Med Date: 2004-11-19 Impact factor: 21.405
Authors: Mehrdad Arjomandi; Josh M Galanter; Shweta Choudhry; Celeste Eng; Donglei Hu; Kenneth Beckman; Rocío Chapela; José R Rodríguez-Santana; William Rodríguez-Cintrón; Jean Ford; Pedro C Avila; Esteban G Burchard Journal: Pediatr Allergy Immunol Pulmonol Date: 2011-12 Impact factor: 1.349
Authors: Albert M Levin; Rasika A Mathias; Lili Huang; Lindsey A Roth; Denise Daley; Rachel A Myers; Blanca E Himes; Isabelle Romieu; Mao Yang; Celeste Eng; Julie E Park; Karla Zoratti; Christopher R Gignoux; Dara G Torgerson; Joshua M Galanter; Scott Huntsman; Elizabeth A Nguyen; Allan B Becker; Moira Chan-Yeung; Anita L Kozyrskyj; Pui-Yan Kwok; Frank D Gilliland; W James Gauderman; Eugene R Bleecker; Benjamin A Raby; Deborah A Meyers; Stephanie J London; Fernando D Martinez; Scott T Weiss; Esteban G Burchard; Dan L Nicolae; Carole Ober; Kathleen C Barnes; L Keoki Williams Journal: J Allergy Clin Immunol Date: 2012-11-10 Impact factor: 10.793
Authors: Joshua M Galanter; Christopher R Gignoux; Dara G Torgerson; Lindsey A Roth; Celeste Eng; Sam S Oh; Elizabeth A Nguyen; Katherine A Drake; Scott Huntsman; Donglei Hu; Saunak Sen; Adam Davis; Harold J Farber; Pedro C Avila; Emerita Brigino-Buenaventura; Michael A LeNoir; Kelley Meade; Denise Serebrisky; Luisa N Borrell; William Rodríguez-Cintrón; Andres Moreno Estrada; Karla Sandoval Mendoza; Cheryl A Winkler; William Klitz; Isabelle Romieu; Stephanie J London; Frank Gilliland; Fernando Martinez; Carlos Bustamante; L Keoki Williams; Rajesh Kumar; José R Rodríguez-Santana; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2014-01-07 Impact factor: 10.793
Authors: Andrés Moreno-Estrada; Christopher R Gignoux; Juan Carlos Fernández-López; Fouad Zakharia; Martin Sikora; Alejandra V Contreras; Victor Acuña-Alonzo; Karla Sandoval; Celeste Eng; Sandra Romero-Hidalgo; Patricia Ortiz-Tello; Victoria Robles; Eimear E Kenny; Ismael Nuño-Arana; Rodrigo Barquera-Lozano; Gastón Macín-Pérez; Julio Granados-Arriola; Scott Huntsman; Joshua M Galanter; Marc Via; Jean G Ford; Rocío Chapela; William Rodriguez-Cintron; Jose R Rodríguez-Santana; Isabelle Romieu; Juan José Sienra-Monge; Blanca del Rio Navarro; Stephanie J London; Andrés Ruiz-Linares; Rodrigo Garcia-Herrera; Karol Estrada; Alfredo Hidalgo-Miranda; Gerardo Jimenez-Sanchez; Alessandra Carnevale; Xavier Soberón; Samuel Canizales-Quinteros; Héctor Rangel-Villalobos; Irma Silva-Zolezzi; Esteban Gonzalez Burchard; Carlos D Bustamante Journal: Science Date: 2014-06-12 Impact factor: 47.728
Authors: Dara G Torgerson; Christopher R Gignoux; Joshua M Galanter; Katherine A Drake; Lindsey A Roth; Celeste Eng; Scott Huntsman; Raul Torres; Pedro C Avila; Rocio Chapela; Jean G Ford; José R Rodríguez-Santana; William Rodríguez-Cintrón; Ryan D Hernandez; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2012-04-13 Impact factor: 10.793
Authors: Rajesh Kumar; Elizabeth A Nguyen; Lindsey A Roth; Sam S Oh; Christopher R Gignoux; Scott Huntsman; Celeste Eng; Andres Moreno-Estrada; Karla Sandoval; Rosenda I Peñaloza-Espinosa; Marisol López-López; Pedro C Avila; Harold J Farber; Haig Tcheurekdjian; William Rodriguez-Cintron; Jose R Rodriguez-Santana; Denise Serebrisky; Shannon M Thyne; L Keoki Williams; Cheryl Winkler; Carlos D Bustamante; Eliseo J Pérez-Stable; Luisa N Borrell; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2013-05-16 Impact factor: 10.793