Literature DB >> 2161982

Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease.

D L Arnold1, P M Matthews, G Francis, J Antel.   

Abstract

Image localized, water-suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N-acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2161982     DOI： 10.1002/mrm.1910140115

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  40 in total

1.  Extended findings of brain metabolite normalization in MA-dependent subjects across sustained abstinence: a proton MRS study.

Authors:  Ruth Salo; Michael H Buonocore; Martin Leamon; Yutaka Natsuaki; Christy Waters; Charles D Moore; Gantt P Galloway; Thomas E Nordahl
Journal:  Drug Alcohol Depend       Date:  2010-08-23       Impact factor: 4.492

Review 2.  Magnetic resonance spectroscopy in the monitoring of multiple sclerosis.

Authors:  Ponnada A Narayana
Journal:  J Neuroimaging       Date:  2005       Impact factor: 2.486

Review 3.  The application of NMR-based metabonomics in neurological disorders.

Authors:  Elaine Holmes; Tsz M Tsang; Sarah J Tabrizi
Journal:  NeuroRx       Date:  2006-07

4.  Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines.

Authors:  D H Miller; F Barkhof; I Berry; L Kappos; G Scotti; A J Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-08       Impact factor: 10.154

5.  Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T.

Authors:  Hetty Prinsen; Robin A de Graaf; Graeme F Mason; Daniel Pelletier; Christoph Juchem
Journal:  J Magn Reson Imaging       Date:  2016-06-28       Impact factor: 4.813

Review 6.  N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.

Authors:  John R Moffett; Brian Ross; Peethambaran Arun; Chikkathur N Madhavarao; Aryan M A Namboodiri
Journal:  Prog Neurobiol       Date:  2007-01-05       Impact factor: 11.685

7.  Lesion discrimination in optic neuritis using high-resolution fat-suppressed fast spin-echo MRI.

Authors:  A Gass; I F Moseley; G J Barker; S Jones; D MacManus; W I McDonald; D H Miller
Journal:  Neuroradiology       Date:  1996-05       Impact factor: 2.804

Review 8.  Magnetic resonance spectroscopy in vivo: applications in neurological disorders.

Authors:  D L Arnold; N De Stefano
Journal:  Ital J Neurol Sci       Date:  1997-12

9.  Global N-acetylaspartate concentration in benign and non-benign multiple sclerosis patients of long disease duration.

Authors:  Lutz Achtnichts; Oded Gonen; Daniel J Rigotti; James S Babb; Yvonne Naegelin; Iris-Katharina Penner; Kerstin Bendfeldt; Jochen Hirsch; Michael Amann; Ludwig Kappos; Achim Gass
Journal:  Eur J Radiol       Date:  2013-09-04       Impact factor: 3.528

10.  Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.

Authors:  Junchao Qian; Juan J Herrera; Ponnada A Narayana
Journal:  J Neurotrauma       Date:  2010-03       Impact factor: 5.269
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.