| Literature DB >> 21619029 |
Abdullah Saleh1, John G D'Angelo, Martha D Morton, Jesse Quinn, Kendra Redden, Rafal W Mielguz, Christopher Pavlik, Michael B Smith.
Abstract
L- and D-glutamic acids, as well as trans-4-hydroxy-L-proline, are converted to the corresponding 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analog. The protecting group used to block the lactam nitrogen in key intermediates has a significant effect on the diastereoselectivity of the coupling reaction with adenine or guanine.Entities:
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Year: 2011 PMID： 21619029 DOI： 10.1021/jo2004617
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354