| Literature DB >> 21618887 |
Paul J Dunford1, Stephen T Holgate.
Abstract
Histamine is a ubiquitous inflammatory mediator intimately associated with the pathology of allergy. Traditional antihistamines, targeting the histamine H1 receptor, have failed to demonstrate a significant role for histamine in asthma. Novel immunomodulatory roles for histamine and the discovery of a novel histamine receptor, the histamine H4 receptor, have resulted in a reassessment of its importance in asthma.Entities:
Mesh：
Substances：
Year: 2010 PMID： 21618887 DOI： 10.1007/978-1-4419-8056-4_6
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622