BACKGROUND: Cancer risk in children born after in vitro fertilization (IVF) remains largely unknown. We aimed to investigate risk of leukemia and lymphoma following IVF using two nationwide datasets. METHODS: The hospital-based case-control study in Greece derived from the National Registry for Childhood Hematological Malignancies (1996-2008, 814 leukemia and 277 lymphoma incident cases with their 1:1 matched controls). The Swedish case-control study was nested in the Swedish Medical Birth Register (MBR) (1995-2007, 520 leukemia and 71 lymphoma cases with their 5,200 and 710 matched controls) with ascertainment of incident cancer cases in the National Cancer Register. Study-specific and combined odds ratios (OR) were estimated using conditional logistic regression, with adjustment for possible risk factors. RESULTS: Nationwide studies pointed to similar size excess risk of leukemia following IVF, but to a null association between IVF and lymphoma. The proportion of leukemia cases conceived through IVF was 3% in Greece and 2.7% in Sweden; prevalence of IVF in matched controls was 1.8% and 1.6%, respectively. In combined multivariable analyses, the increased risk of leukemia was confined to age below 3.8 years (OR = 2.21; 95% confidence interval, CI: 1.27-3.85) and to acute lymphoblastic leukemia (ALL) (OR = 1.77; 95% CI: 1.06-2.95) with no sufficient evidence of excess risk for other leukemias (OR = 1.34; 95% CI: 0.38-4.69). Following IVF, OR for ALL was 2.58 (95% CI: 1.37-4.84) before age 3.8 and 4.29 (95% CI: 1.49-12.37) before age 2 years. CONCLUSIONS: IVF seems to be associated with increased risk of early onset ALL in the offspring.
BACKGROUND:Cancer risk in children born after in vitro fertilization (IVF) remains largely unknown. We aimed to investigate risk of leukemia and lymphoma following IVF using two nationwide datasets. METHODS: The hospital-based case-control study in Greece derived from the National Registry for Childhood Hematological Malignancies (1996-2008, 814 leukemia and 277 lymphoma incident cases with their 1:1 matched controls). The Swedish case-control study was nested in the Swedish Medical Birth Register (MBR) (1995-2007, 520 leukemia and 71 lymphoma cases with their 5,200 and 710 matched controls) with ascertainment of incident cancer cases in the National Cancer Register. Study-specific and combined odds ratios (OR) were estimated using conditional logistic regression, with adjustment for possible risk factors. RESULTS: Nationwide studies pointed to similar size excess risk of leukemia following IVF, but to a null association between IVF and lymphoma. The proportion of leukemia cases conceived through IVF was 3% in Greece and 2.7% in Sweden; prevalence of IVF in matched controls was 1.8% and 1.6%, respectively. In combined multivariable analyses, the increased risk of leukemia was confined to age below 3.8 years (OR = 2.21; 95% confidence interval, CI: 1.27-3.85) and to acute lymphoblastic leukemia (ALL) (OR = 1.77; 95% CI: 1.06-2.95) with no sufficient evidence of excess risk for other leukemias (OR = 1.34; 95% CI: 0.38-4.69). Following IVF, OR for ALL was 2.58 (95% CI: 1.37-4.84) before age 3.8 and 4.29 (95% CI: 1.49-12.37) before age 2 years. CONCLUSIONS:IVF seems to be associated with increased risk of early onset ALL in the offspring.
Authors: Marie Hargreave; Allan Jensen; Isabelle Deltour; Louise A Brinton; Klaus K Andersen; Susanne K Kjaer Journal: Int J Cancer Date: 2013-03-25 Impact factor: 7.396
Authors: Theodoros N Sergentanis; Thomas P Thomopoulos; Spyros P Gialamas; Maria A Karalexi; Stylianos-Iason Biniaris-Georgallis; Evangelia Kontogeorgi; Paraskevi Papathoma; Gerasimos Tsilimidos; Alkistis Skalkidou; Anastasia N Iliadou; Eleni T Petridou Journal: Eur J Epidemiol Date: 2015-11-04 Impact factor: 8.082
Authors: Catherine Metayer; Elizabeth Milne; Jacqueline Clavel; Claire Infante-Rivard; Eleni Petridou; Malcolm Taylor; Joachim Schüz; Logan G Spector; John D Dockerty; Corrado Magnani; Maria S Pombo-de-Oliveira; Daniel Sinnett; Michael Murphy; Eve Roman; Patricia Monge; Sameera Ezzat; Beth A Mueller; Michael E Scheurer; Bruce K Armstrong; Jill Birch; Peter Kaatsch; Sergio Koifman; Tracy Lightfoot; Parveen Bhatti; Melissa L Bondy; Jérémie Rudant; Kate O'Neill; Lucia Miligi; Nick Dessypris; Alice Y Kang; Patricia A Buffler Journal: Cancer Epidemiol Date: 2013-02-09 Impact factor: 2.984