Literature DB >> 21617767

Abronione, a rotenoid from the desert annual Abronia villosa.

Courtney M Starks1, Russell B Williams, Vanessa L Norman, Julie A Lawrence, Matt G Goering, Mark O'Neil-Johnson, Jin-Feng Hu, Stephanie M Rice, Gary R Eldridge.   

Abstract

A high-throughput phytochemical investigation of Abronia villosa afforded a new rotenoid designated abronione (1) along with the known compounds boeravinone C and lupeol. The structure of 1 was determined using NMR, MS, and optical analysis with < 400 µg of material. Compound 1 displayed moderate cytotoxicity against NCI-H460 and HL-60 human cancer cell lines with IC(50) values of 14 and 36 µM, respectively.

Entities:  

Year:  2011        PMID： 21617767      PMCID： PMC3099468          DOI： 10.1016/j.phytol.2010.08.004

Source DB:  PubMed          Journal:  Phytochem Lett        ISSN： 1874-3900            Impact factor:   1.679


  7 in total

1.  Application of capillary-scale NMR for the structure determination of phytochemicals.

Authors:  Jin-Feng Hu; Eliane Garo; Hye-Dong Yoo; Peadar A Cremin; Lu Zeng; Matt G Goering; Mark O'Neil-Johnson; Gary R Eldridge
Journal:  Phytochem Anal       Date:  2005 Mar-Apr       Impact factor: 3.373

2.  Cubé resin insecticide: identification and biological activity of 29 rotenoid constituents.

Authors:  N Fang; J E Casida
Journal:  J Agric Food Chem       Date:  1999-05       Impact factor: 5.279

3.  Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities.

Authors:  N Fang; J E Casida
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

4.  A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.

Authors:  Woo-Young Kim; Dong Jo Chang; Bryan Hennessy; Hae Jin Kang; Jakyung Yoo; Seung-Ho Han; Yoo-Shin Kim; Hyun-Ju Park; Seung-Yong Seo; Seung-Yong Geo; Gordon Mills; Kyu-Won Kim; Waun Ki Hong; Young-Ger Suh; Ho-Young Lee
Journal:  Cancer Prev Res (Phila)       Date:  2008-12

5.  Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

Authors:  Seung Hyun Oh; Jong Kyu Woo; Yasemin Dakak Yazici; Jeffrey N Myers; Woo-Young Kim; Quanri Jin; Soon Sun Hong; Hyun-Ju Park; Young-Ger Suh; Kyu-Won Kim; Waun Ki Hong; Ho-Young Lee
Journal:  J Natl Cancer Inst       Date:  2007-06-12       Impact factor: 13.506

6.  High-throughput method for the production and analysis of large natural product libraries for drug discovery.

Authors:  Gary R Eldridge; Hélène C Vervoort; Chris M Lee; Peadar A Cremin; Caroline T Williams; Shane M Hart; Matt G Goering; Mark O'Neil-Johnson; Lu Zeng
Journal:  Anal Chem       Date:  2002-08-15       Impact factor: 6.986

7.  Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors.

Authors:  Abdelhakim Ahmed-Belkacem; Sira Macalou; Francesca Borrelli; Raffaele Capasso; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Attilio Di Pietro
Journal:  J Med Chem       Date:  2007-03-07       Impact factor: 7.446
  7 in total

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