Literature DB >> 21617370

Sex differences in epigenetic mechanisms may underlie risk and resilience for mental health disorders.

Heather M Jessen1, Anthony P Auger.   

Abstract

Alterations in the epigenetic programming of sex differences in the brain may underlie sexually dimorphic neurodevelopmental disorders. Sex differences have been found in DNA methyltransferases 3a, DNA methylation patterns, MeCP2, and nuclear corepressor within the developing brain. Natural variations in these epigenetic mechanisms have profound consequences on gene expression and brain function. Exogenous or endogenous perturbations during development may impact these epigenetic processes and alter the trajectory of the developing brain and confer sexually dimorphic risk and resilience for developing a neurological or mental health disorder.

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Year:  2011        PMID： 21617370      PMCID： PMC3154426          DOI： 10.4161/epi.6.7.16517

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  46 in total

1.  Sex difference in the expression of DNA methyltransferase 3a in the rat amygdala during development.

Authors:  M H Kolodkin; A P Auger
Journal:  J Neuroendocrinol       Date:  2011-07       Impact factor: 3.627

2.  Sex differences in epigenetic regulation of the estrogen receptor-alpha promoter within the developing preoptic area.

Authors:  Joseph R Kurian; Kristin M Olesen; Anthony P Auger
Journal:  Endocrinology       Date:  2010-03-17       Impact factor: 4.736

3.  Epigenetic control of vasopressin expression is maintained by steroid hormones in the adult male rat brain.

Authors:  Catherine J Auger; Dylan Coss; Anthony P Auger; Robin M Forbes-Lorman
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-22       Impact factor: 11.205

4.  Epigenetic impact of simulated maternal grooming on estrogen receptor alpha within the developing amygdala.

Authors:  Michelle N Edelmann; Anthony P Auger
Journal:  Brain Behav Immun       Date:  2011-02-23       Impact factor: 7.217

5.  Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.

Authors:  Jian Feng; Yu Zhou; Susan L Campbell; Thuc Le; En Li; J David Sweatt; Alcino J Silva; Guoping Fan
Journal:  Nat Neurosci       Date:  2010-03-14       Impact factor: 24.884

6.  The nuclear receptor corepressor has organizational effects within the developing amygdala on juvenile social play and anxiety-like behavior.

Authors:  Heather M Jessen; Mira H Kolodkin; Meaghan E Bychowski; Catherine J Auger; Anthony P Auger
Journal:  Endocrinology       Date:  2010-01-05       Impact factor: 4.736

7.  Mecp2 organizes juvenile social behavior in a sex-specific manner.

Authors:  Joseph R Kurian; Meaghan E Bychowski; Robin M Forbes-Lorman; Catherine J Auger; Anthony P Auger
Journal:  J Neurosci       Date:  2008-07-09       Impact factor: 6.167

8.  Cyclical DNA methylation of a transcriptionally active promoter.

Authors:  Raphaël Métivier; Rozenn Gallais; Christophe Tiffoche; Christine Le Péron; Renata Z Jurkowska; Richard P Carmouche; David Ibberson; Peter Barath; Florence Demay; George Reid; Vladimir Benes; Albert Jeltsch; Frank Gannon; Gilles Salbert
Journal:  Nature       Date:  2008-03-06       Impact factor: 49.962

9.  Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.

Authors:  Quincey LaPlant; Vincent Vialou; Herbert E Covington; Dani Dumitriu; Jian Feng; Brandon L Warren; Ian Maze; David M Dietz; Emily L Watts; Sergio D Iñiguez; Ja Wook Koo; Ezekiell Mouzon; William Renthal; Fiona Hollis; Hui Wang; Michele A Noonan; Yanhua Ren; Amelia J Eisch; Carlos A Bolaños; Mohamed Kabbaj; Guanghua Xiao; Rachael L Neve; Yasmin L Hurd; Ronald S Oosting; Gouping Fan; John H Morrison; Eric J Nestler
Journal:  Nat Neurosci       Date:  2010-08-22       Impact factor: 24.884

Review 10.  Eloquent silence: developmental functions of Class I histone deacetylases.

Authors:  Vincent T Cunliffe
Journal:  Curr Opin Genet Dev       Date:  2008-10-16       Impact factor: 5.578
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  24 in total

1.  Exposure to caregiver maltreatment alters expression levels of epigenetic regulators in the medial prefrontal cortex.

Authors:  Jennifer Blaze; Tania L Roth
Journal:  Int J Dev Neurosci       Date:  2013-10-10       Impact factor: 2.457

2.  Comparison of children with autism spectrum disorder with and without schizophrenia spectrum traits: gender, season of birth, and mental health risk factors.

Authors:  Kenneth D Gadow; Carla J DeVincent
Journal:  J Autism Dev Disord       Date:  2012-11

Review 3.  Experience and the developing prefrontal cortex.

Authors:  Bryan Kolb; Richelle Mychasiuk; Arif Muhammad; Yilin Li; Douglas O Frost; Robbin Gibb
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-08       Impact factor: 11.205

4.  Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G.

Authors:  Y-J Wang; P Huang; A Ung; J A Blendy; L-Y Liu-Chen
Journal:  Neuroscience       Date:  2012-01-03       Impact factor: 3.590

Review 5.  Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence.

Authors:  Monica Uddin; Levent Sipahi; Jia Li; Karestan C Koenen
Journal:  Depress Anxiety       Date:  2013-08-19       Impact factor: 6.505

6.  Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment.

Authors:  Tiffany S Doherty; Amy Forster; Tania L Roth
Journal:  Behav Brain Res       Date:  2015-05-28       Impact factor: 3.332

Review 7.  Epigenetic mechanisms in pubertal brain maturation.

Authors:  K E Morrison; A B Rodgers; C P Morgan; T L Bale
Journal:  Neuroscience       Date:  2013-11-15       Impact factor: 3.590

8.  Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum.

Authors:  Therese A Kosten; David A Nielsen
Journal:  Int J Dev Neurosci       Date:  2014-04-08       Impact factor: 2.457

9.  Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G.

Authors:  Yu-Jun Wang; Peng Huang; Julie A Blendy; Lee-Yuan Liu-Chen
Journal:  Addict Biol       Date:  2012-08-02       Impact factor: 4.280

10.  Differential methylation of genes in the medial prefrontal cortex of developing and adult rats following exposure to maltreatment or nurturing care during infancy.

Authors:  Jennifer Blaze; Lisa Scheuing; Tania L Roth
Journal:  Dev Neurosci       Date:  2013-06-08       Impact factor: 2.984
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