| Literature DB >> 2161678 |
C H Marquette1, M Joseph, A B Tonnel, H Vorng, P Lassalle, A Tsicopoulos, A Capron.
Abstract
1. Blood platelets from patients with aspirin-sensitive asthma (ASA) generated cytotoxic mediators in the presence of aspirin. This abnormal in vitro response to aspirin was abolished within 1 h after nedocromil sodium inhalation but not after sodium cromoglycate inhalation. 2. Platelets recovered this reactivity to aspirin by 12 hours after nedocromil sodium treatment of ASA-patients. 3. The in vitro reactivity to aspirin of ASA platelets isolated before inhalation was inhibited in the presence of serum isolated 15 and 60 min after nedocromil sodium inhalation.Entities:
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Year: 1990 PMID: 2161678 PMCID: PMC1380151 DOI: 10.1111/j.1365-2125.1990.tb03675.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN: 0306-5251 Impact factor: 4.335