Literature DB >> 21616123

Regulator of G protein signaling 9-2 (RGS9-2) mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells.

Meenakshi Sharma1, Jeremy Celver, Abraham Kovoor.   

Abstract

In this study we demonstrate up-regulation of mRNA for Regulator of G protein Signaling (RGS) 6, 7, 9 and 11, R7 family RGS binding protein (R7BP) and RGS9 anchor protein (R9AP) during neuronal differentiation of mouse embryonic stem cells (mESCs). This expression pattern was most robust for RGS9 whose transcript level was low in undifferentiated mESCs but increased over 125 fold when differentiating mESCs began to exhibit a neuronal precursor cell (NPC) phenotype. In addition, we demonstrate that RGS9 mRNA is expressed in neuronal stem cells isolated from embryonic mouse cortex. The expression of RGS9 in two distinct populations of NPCs suggests that RGS9 and its accessory proteins may play an important role in neuron development.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 21616123      PMCID： PMC3212853          DOI： 10.1016/j.neulet.2011.05.021

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  29 in total

1.  D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.

Authors:  Abraham Kovoor; Petra Seyffarth; Jana Ebert; Sami Barghshoon; Ching-Kang Chen; Sigrid Schwarz; Jeffrey D Axelrod; Benjamin N R Cheyette; Melvin I Simon; Henry A Lester; Johannes Schwarz
Journal:  J Neurosci       Date:  2005-02-23       Impact factor: 6.167

2.  Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.

Authors:  S J Gold; Y G Ni; H G Dohlman; E J Nestler
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

3.  Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.

Authors:  C Lois; A Alvarez-Buylla
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

4.  Perinatal hypoxic/ischemic brain injury induces persistent production of striatal neurons from subventricular zone progenitors.

Authors:  Zhengang Yang; Steven W Levison
Journal:  Dev Neurosci       Date:  2007       Impact factor: 2.984

5.  Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system.

Authors:  Gabor Keresztes; Hideki Mutai; Hiroshi Hibino; A J Hudspeth; Stefan Heller
Journal:  Mol Cell Neurosci       Date:  2003-11       Impact factor: 4.314

6.  Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.

Authors:  K M Druey; K J Blumer; V H Kang; J H Kehrl
Journal:  Nature       Date:  1996-02-22       Impact factor: 49.962

7.  The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.

Authors:  Kirill A Martemyanov; Polina V Lishko; Nidia Calero; Gabor Keresztes; Maxim Sokolov; Katherine J Strissel; Ilya B Leskov; Johnathan A Hopp; Alexander V Kolesnikov; Ching-Kang Chen; Janis Lem; Stefan Heller; Marie E Burns; Vadim Y Arshavsky
Journal:  J Neurosci       Date:  2003-11-12       Impact factor: 6.167

8.  Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain.

Authors:  D Grabowska; M Jayaraman; K M Kaltenbronn; S L Sandiford; Q Wang; S Jenkins; V Z Slepak; Y Smith; K J Blumer
Journal:  Neuroscience       Date:  2007-12-08       Impact factor: 3.590

9.  Niche-independent symmetrical self-renewal of a mammalian tissue stem cell.

Authors:  Luciano Conti; Steven M Pollard; Thorsten Gorba; Erika Reitano; Mauro Toselli; Gerardo Biella; Yirui Sun; Sveva Sanzone; Qi-Long Ying; Elena Cattaneo; Austin Smith
Journal:  PLoS Biol       Date:  2005-08-16       Impact factor: 8.029

10.  Generation of purified neural precursors from embryonic stem cells by lineage selection.

Authors:  M Li; L Pevny; R Lovell-Badge; A Smith
Journal:  Curr Biol       Date:  1998-08-27       Impact factor: 10.834
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  1 in total

1.  Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons.

Authors:  Takahiro Ishimoto; Noritaka Nakamichi; Hiroshi Hosotani; Yusuke Masuo; Tomoko Sugiura; Yukio Kato
Journal:  PLoS One       Date:  2014-02-25       Impact factor: 3.240
  1 in total

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