Literature DB >> 21615531

In vitro antifungal evaluation and structure-activity relationship of diphenyl diselenide and synthetic analogues.

Erico Silva Loreto1, Débora Alves Nunes Mario, Janio Morais Santurio, Sydney Hartz Alves, Cristina Wayne Nogueira, Gilzon Zeni.   

Abstract

We report on in vitro antifungal activity and the structure-activity relationship of diphenyl diselenide [(PhSe)(2) ] and its synthetic analogues, (p-Cl-C(6) H(4) Se)(2), (m-CF(3)-C(6) H(4)Se)(2) and (p-CH(3)O-C(6) H(4)Se)(2), against 116 strains of pathogenic fungi. (PhSe)(2) showed the highest inhibitory activity against Candida albicans (minimum inhibitory concentration of 4-32 μg ml(-1) ), Candida dubliniensis (2-16 μg ml(-1)), Aspergillus spp. (0.5-64 μg ml(-1)) and Fusarium spp. (2-16 μg ml(-1)). Its minimum fungicidal concentration (MFC) varied among C. albicans (4-64 μg ml(-1)), C. dubliniensis (2-32 μg ml(-1) ) and Fusarium spp. (4-64 μg ml(-1)). Antifungal activity was decreased by the introduction of functional groups to the (PhSe)(2) molecule: (PhSe)(2) >(p-CH(3)O-C(6)H(4) Se)(2) >(m-CF(3)-C(6)H(4)Se)(2) >(p-Cl-C(6) H(4)Se)(2).
© 2011 Blackwell Verlag GmbH.

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Year:  2011        PMID： 21615531     DOI： 10.1111/j.1439-0507.2010.01994.x

Source DB:  PubMed          Journal:  Mycoses        ISSN： 0933-7407            Impact factor:   4.377


  6 in total

1.  Antifungal activities of diphenyl diselenide alone and in combination with fluconazole or amphotericin B against Candida glabrata.

Authors:  Laura Bedin Denardi; Débora Alves Nunes Mario; Erico Silva de Loreto; Cristina Wayne Nogueira; Janio Morais Santurio; Sydney Hartz Alves
Journal:  Mycopathologia       Date:  2013-06-23       Impact factor: 2.574

2.  In Vitro Activity of Ebselen and Diphenyl Diselenide Alone and in Combination with Drugs against Trichophyton mentagrophytes Strains.

Authors:  Sebastian Gnat; Dominik Łagowski; Mariusz Dyląg; Grzegorz Jóźwiak; Aleksandra Trościańczyk; Aneta Nowakiewicz
Journal:  Pharmaceutics       Date:  2022-05-28       Impact factor: 6.525

3.  Diphenyl diselenide alone and in combination with itraconazole against Sporothrix schenckii s.str. and Sporothrix globosa.

Authors:  Vanice Rodrigues Poester; Lívia Silveira Munhoz; Cristina Wayne Nogueira; Gilson Rogério Zeni; David A Stevens; Melissa Orzechowski Xavier
Journal:  Braz J Microbiol       Date:  2021-04-28       Impact factor: 2.476

4.  Reaction of bis[(2-chlorocarbonyl)phenyl] Diselenide with Phenols, Aminophenols, and Other Amines towards Diphenyl Diselenides with Antimicrobial and Antiviral Properties.

Authors:  Mirosław Giurg; Anna Gołąb; Jakub Suchodolski; Rafał Kaleta; Anna Krasowska; Egbert Piasecki; Magdalena Piętka-Ottlik
Journal:  Molecules       Date:  2017-06-12       Impact factor: 4.411

5.  Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection.

Authors:  Luca Sancineto; Miranda Piccioni; Stefania De Marco; Rita Pagiotti; Vanessa Nascimento; Antonio Luiz Braga; Claudio Santi; Donatella Pietrella
Journal:  BMC Microbiol       Date:  2016-09-21       Impact factor: 3.605

6.  Anti-tubercular profile of new selenium-menadione conjugates against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain and multidrug-resistant clinical isolates.

Authors:  Ruan C B Ribeiro; Daniel B de Marins; Iris Di Leo; Luana da Silva Gomes; Matheus G de Moraes; Bruno L Abbadi; Anne D Villela; Wellington F da Silva; Luiz Cláudio R P da Silva; Pablo Machado; Cristiano Valim Bizarro; Luiz Augusto Basso; Marcela Cristina de Moraes; Vitor F Ferreira; Fernando de C da Silva; Vanessa Nascimento
Journal:  Eur J Med Chem       Date:  2020-09-23       Impact factor: 6.514
  6 in total

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