PURPOSE: The purpose of this paper is to evaluate concentrations of multiple oxidative stress and antioxidant status markers in patients with obstructive sleep apnea (OSA) and normal controls of comparable obesity. METHODS: A total of 73 male subjects, recruited from a sleep clinic or advertisements, were enrolled in this study. All subjects underwent overnight polysomnography. The subjects were divided into normal control (n = 20), mild to moderate OSA (n = 31), and severe OSA (n = 22) with no difference in obesity. Blood was withdrawn from subjects, and markers of oxidative stress and antioxidant status, and parameters of glucose metabolism were assessed. RESULTS: There was no significant difference in either oxidative stress or antioxidant status markers among the three groups. There was no significant correlation between the oxidative stress markers and the OSA variables. However, there were correlations between waist-to-hip ratio (WHR)-oxidized low-density lipoprotein cholesterol (oxLDL) (r = 0.424), WHR-glutathione peroxidase (GPX) (r = 0.318), WHR-total antioxidant status (TAS) (r = -0.317), and WHR-superoxide dismutase (SOD) (r = -0.338). In multiple regression analysis, WHR was a significant independent variable of oxLDL, GPX, TAS, and SOD. CONCLUSIONS: The oxidative stress in OSA was related to central obesity rather than intermittent hypoxia or respiratory disturbances. To control cardiovascular complications in OSA, weight reduction should be a component in the treatment strategy.
PURPOSE: The purpose of this paper is to evaluate concentrations of multiple oxidative stress and antioxidant status markers in patients with obstructive sleep apnea (OSA) and normal controls of comparable obesity. METHODS: A total of 73 male subjects, recruited from a sleep clinic or advertisements, were enrolled in this study. All subjects underwent overnight polysomnography. The subjects were divided into normal control (n = 20), mild to moderate OSA (n = 31), and severe OSA (n = 22) with no difference in obesity. Blood was withdrawn from subjects, and markers of oxidative stress and antioxidant status, and parameters of glucose metabolism were assessed. RESULTS: There was no significant difference in either oxidative stress or antioxidant status markers among the three groups. There was no significant correlation between the oxidative stress markers and the OSA variables. However, there were correlations between waist-to-hip ratio (WHR)-oxidized low-density lipoprotein cholesterol (oxLDL) (r = 0.424), WHR-glutathione peroxidase (GPX) (r = 0.318), WHR-total antioxidant status (TAS) (r = -0.317), and WHR-superoxide dismutase (SOD) (r = -0.338). In multiple regression analysis, WHR was a significant independent variable of oxLDL, GPX, TAS, and SOD. CONCLUSIONS: The oxidative stress in OSA was related to central obesity rather than intermittent hypoxia or respiratory disturbances. To control cardiovascular complications in OSA, weight reduction should be a component in the treatment strategy.
Authors: John F Keaney; Martin G Larson; Ramachandran S Vasan; Peter W F Wilson; Izabella Lipinska; Diane Corey; Joseph M Massaro; Patrice Sutherland; Joseph A Vita; Emelia J Benjamin Journal: Arterioscler Thromb Vasc Biol Date: 2003-01-30 Impact factor: 8.311
Authors: Yüksel Peker; Jan Hedner; Jeanette Norum; Holger Kraiczi; Jan Carlson Journal: Am J Respir Crit Care Med Date: 2002-07-15 Impact factor: 21.405
Authors: J D Morrow; B Frei; A W Longmire; J M Gaziano; S M Lynch; Y Shyr; W E Strauss; J A Oates; L J Roberts Journal: N Engl J Med Date: 1995-05-04 Impact factor: 91.245
Authors: R V Considine; M K Sinha; M L Heiman; A Kriauciunas; T W Stephens; M R Nyce; J P Ohannesian; C C Marco; L J McKee; T L Bauer Journal: N Engl J Med Date: 1996-02-01 Impact factor: 91.245
Authors: Graziela De Luca Canto; Camila Pachêco-Pereira; Secil Aydinoz; Paul W Major; Carlos Flores-Mir; David Gozal Journal: Sleep Med Rev Date: 2014-11-28 Impact factor: 11.609
Authors: A Sánchez-Armengol; P Villalobos-López; C Caballero-Eraso; C Carmona-Bernal; M Asensio-Cruz; F Barbé; F Capote Journal: Sleep Breath Date: 2015-01-27 Impact factor: 2.816
Authors: Graziela De Luca Canto; Camila Pachêco-Pereira; Secil Aydinoz; Paul W Major; Carlos Flores-Mir; David Gozal Journal: J Clin Sleep Med Date: 2015-01-15 Impact factor: 4.062
Authors: Shikha S Sundaram; Ann Halbower; Zhaoxing Pan; Kristen Robbins; Kelley E Capocelli; Jelena Klawitter; Colin T Shearn; Ronald J Sokol Journal: J Hepatol Date: 2016-08-05 Impact factor: 25.083